RE:“Highly likely to succeed”If a minimum amount of successful trial outcomes defines trial success, and they are exceeding expectations, and they know this because the trial not double blind...
Can't the trial be labeled a success prior to completion of the entire cohort since success is inevitable if they reach the minimum successful trial outcomes early. In a normal trial data is double blind until the end so the researchers don't know this. In the pmx trial, they already know.
I don't see rationale for continuing the trial with known success especially combined with the already existing real world data. They would be completing the trial only to go 'through the motions.'