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The endocannabinoid system (ECS) is an ancient system that is believed to have evolved over 500 million years ago. It is wired throughout the bodies of humans and all vertebrates and invertebrates, and designed to help maintain homeostasis — balance of processes — in the body.
Though the ECS appears to be an ancient system, scientists discovered it only recently, in the context of research exploring the effects of
cannabis (marijuana and hemp) on the mind and body.
In the course of this work, scientists discovered that the human body has cannabinoid receptors — cell proteins that respond to chemicals — distributed throughout the body. They also discovered that the human body makes a class of chemicals known as endocannabinoids that interact with these receptors to affect health.
Two of the main active compounds in cannabis, THC (tetrahydrocannabinol) and CBD (cannabidiol) — called plant or phytocannabinoids — are chemically similar to the natural endocannabinoids produced by the human body.
The discovery of the ECS, coupled with the awareness of plant cannabinoids and the opportunity to make synthetic (or human-made) versions has generated a substantial amount of scientific interest in understanding how cannabinoids might be used to maintain health and alleviate symptoms of disease.