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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Comment by Noteableon Dec 05, 2023 5:40pm
133 Views
Post# 35769972

RE:RE:RE:AA ?

RE:RE:RE:AA ?OK ...  it confirmed it.

And by virtue of the Bracelet-1 results th
e study results went on to interpretedly confirm that pelareorep + paclitaxel + atezolizumab was effective in advanced or metastatic pancreatic cancer AND that this combination would very likely be effective in metastatic breast cancer since atezolizumab is a PD-L1 blocker that has its Fc component silenced.  Unlike Avelumab, a PD-L1 inhibitor, which was used in the pelareorep + paclitaxel + Avelumab cohort of the Phase 2 Bracelet-1 clinical study, the PD-L1 inhibitor atezolizumab has its Fc protein component silenced and is synergistic in combination with pelareorep.


https://www.prnewswire.com/news-releases/oncolytics-biotech-announces-updated-randomized-phase-2-data-from-bracelet-1-metastatic-breast-cancer-trial-that-show-pelareorep-driving-robust-increases-in-progression-free-survival-and-confirmed-overall-response-rate-301842058.html


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