RE:EU approves first I/O combinationONCY's pelareorep in combination with CPIs and chemotherapy (n-paclitaxel) results in priming of the immune system, an increase in TiLs and T-cell clonality, and the remodeling of the TME to facilitate the addition of CPIs.
Patients developed new T-cell clones and increased peripheral T-cell clonality, leading to an inflamed tumour.
“We see a lot more T cells around the tumor, and they’re in attack mode. T cells are an important immune cell type, like a SWAT team that can recognize tumor cells and pump them full of enzymes that chew up the tumor from the inside out.”