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Oncolytics Biotech Inc ONCY


Primary Symbol: T.ONC

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > AstraZeneca's ADC disappoints - on severe adverse events
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Comment by Noteableon Apr 09, 2024 10:42am
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Post# 35978942

RE:RE:RE:AstraZeneca's ADC disappoints - on severe adverse events

RE:RE:RE:AstraZeneca's ADC disappoints - on severe adverse eventsApril 09, 2024 - AACR24 -  An AACR poster on Vincerx's VIP236, a small-molecule drug conjugate that targets αvβ3 and is the company’s most advanced asset, has revealed zero objective responses among 15 patients, prompting a 70% share price collapse in Vincerx this morning. 

The AACR poster concerned a phase 1 study, which enrolled patients with solid tumours not preselected for αvβ3 expression. Vincerx claimed that it would have been difficult to biopsy some solid tumours, but said that αvβ3 was very commonly expressed.

If this is indeed the case then VIP236 doesn’t appear to work particularly well. 

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