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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > review article - may 1st
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Post by spesestsemperon May 03, 2024 1:30pm
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Post# 36022052

review article - may 1st

review article - may 1stFrontiers | Frontiers and future of immunotherapy for pancreatic cancer: from molecular mechanisms to clinical application (frontiersin.org)

Notably, pelareorep (62), an intravenously delivered oncolytic reovirus, is known to induce a T-cell inflammatory phenotype in PDAC. A phase Ib study (63) that evaluated pembrolizumab combined with pelareorep and chemotherapy included 11 patients with advanced pancreatic cancer. Efficacy of the combination was demonstrated in 10 patients, among whom 3 experienced disease control. One patient demonstrated partial response for up to 17.4 months; the 2 other patients had stable disease for 9 and 4 months, respectively. These results demonstrated that the addition of pelareorep and pembrolizumab to chemotherapy offered good efficacy without any significant increase in toxicity.
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