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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > Resistance to ADCs in the treatment of solid tumors
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Comment by Noteableon May 18, 2024 1:48pm
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Post# 36047400

RE:RE:Resistance to ADCs in the treatment of solid tumors

RE:RE:Resistance to ADCs in the treatment of solid tumors March 06, 2024 - The UK’s National Institute for Health and Care Excellence (NICE) has announced that it will not recommend the use of fam-trastuzumab deruxtecan-nxki (Enhertu; T-DXd) for the treatment of patients with HER2-low breast cancer.

[ NICE effectively implied that despite the reported improvement in OS and PFS Enhertu, the categorization of the ADC could not be expanded beyond HER2-positive, nothwithstanding approval of the HER2-low/ultralow re-categorization in the US and Japan, for example ]

https://www.onclive.com/view/t-dxd-fails-to-receive-recommendation-from-nice-for-her2-low-breast-cancer-treatment
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