RE:Immunotherapy: Oncolytic Viruses now on stageInteresting work on how CD8+ T cells help kill cells infected with a virus, particularly knowing that pelareorep is able to stimulate the immune system and expand CD8+ TiLs cells in the tumor microenvironment (TME) and remodel the TME.
In a cancer, pelareorep is the virus in the above mechanism and is able to remodel the TME, and in so doing in advance of the addition of an immune checkpoint inhibitor, pelareorep is able to turn a cold tumor into a hot tumor, which becomes receptive to checkpoint inhibition, making checkpoint inhibitors more effective in the treatment of cancer.
https://www.technologynetworks.com/immunology/news/immunotherapy-could-be-used-to-boost-the-immune-system-of-older-individuals-386793