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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Comment by jfm1330on May 24, 2024 2:43pm
140 Views
Post# 36056371

RE:RE:RE:New Press Release - Theratechnologies' Sudocetaxel Zendusortide ASCO 2024 Presentation Demonstrates Signs of Long-Term Efficacy and Manageable Safety Profile in Patients with Solid Tumors

RE:RE:RE:New Press Release - Theratechnologies' Sudocetaxel Zendusortide ASCO 2024 Presentation Demonstrates Signs of Long-Term Efficacy and Manageable Safety Profile in Patients with Solid TumorsStable disease for many years is a very good outcome on advanced patients. Take my word for that. That being said, approval through progression free survival (PFS) takes much longere than through tumor shrinkage, partial response or complete response. So they are in for the long run if results are good enough. That's why they will need a partner and they will have to sell a big part of the rights to attract such a partner. But selling part of the rights to the whole thing, i mean future PDCs with different warheads like SN38 could be attractive.

That being said, I still think that having a their peptide coupled with Ga68 for imaging in humans would have been a very good tool to have. If they would be able to show tumor accumulation in humans through such imaging it would help them so much to show proof of concept for the whole platform. But it's too late for that and they don't have the financial means to develop that themselves. All their lab people were laid off. So it will be like F2, F4 and F8, they will do it 10 years too late.
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