RE:RE:RE:RE:RE:RE:RE:RE:New Press Release - Theratechnologies' Sudocetaxel Zendusortide ASCO 2024 Presentation Demonstrates Signs of Long-Term Efficacy and Manageable Safety Profile in Patients with Solid TumorsI don't know if I really feel like I recovered asI felt fine before getting my stents, the procedure placing the stents was a breeze and I have felt fine ever since. The only improvement I have noticed is I don't sweat as much as before when doing somethign physical. I really never felt bad, just had some relatively minor twinges in my right pec which was the only indication my body was willing to give me that I was actually 99% blocked in my right coronary artery and 70-80% blocked in the widowmaker. Fortunately, it was just enough to get it taken care of in the nick of time but not before some struggles with insurance coverage over what turned out to be the key test and hassles with getting the doctor to actually read that test. I know you are aware of my story but others reading may not knwo what you were referring to so I thought I would give them a quick summary.
jfm1330 wrote: Thanks for your good words and thoughts SPCEO. I hope you are recovering well from your own health problems.
SPCEO1 wrote: I am glad there are other treatment options for you but sad to hear of your declining quality of life. You have battled this beast for a very long time and I am sure it takes an emotional as well as physical toll. I doubt many of us would have had the stamina you have shown. And thanks for keeping an eye on this board in the midst of that and weighing in with your always helpful insights. I would be quite happy if there is some way THTX could pull a rabbit out of their TH-1902 hat but I would be much, much happier if you saw a miraculously positive turn in your health. In my personal Bible reading at the moent I am in the early chapters of the book of Matthew and over and over again it reveals Jesus healing everyone He could. I will keep praying there may be a miracle in your future too. The only thing Jesus ever asked of someone being healed by Him was that they express faith in Him and His ability to heal them. If you are uncomfortable with that, I will try to have that faith for you.
Thanks again for your ongoing wisdom regarding TH-1902.
jfm1330 wrote: If all they have on humans is stable disease, even on half of the patients, it will be hard to attract a partner, again, because it means the long and costly road to approval and they have nothing else to show proof of concept. So hopefully they can have a few partial responses or some biomarkers data. I don't know if there is a proven biomarker to assess evolution of ovarian cancer.
In the case of my cancer, which is neuroendocrine cancer, there is a biomarker a protein called chromogranin, but more and more there is data showing it is not a reliable indicator. In my last meeting with my oncologist this week, she told me she would request the analysis to be done just to compare with my previous results on that, but she was now doubtful about it.
Cancer is a very tricky thing. In my case they tell me that Ga68 Pet scan shows a stable disease based on tumor load and absence of new tumors, but I feel worst as time goes by. So cancer progression is not all about tumor progression. Tumor biochemical evolution is very important, as well as genetic evolution (mutations) but it is impossible to evaluate that on a routine basis in the medical labs of hospitals. They do standardized analyses, they are not a research lab. Cancer in its variety is a complex thing that is very hard to fully assess even in a research lab. In the standardized hospital setting, it relies mainly on imaging, but you cannot have a scan every month. So you are in the dark for many months trying to interpret what you feel in your body, but it's often misleading.
This week I met with my oncologist and told her that the last three months were worrying to me because I feel like I am declining physically and that I was wondering if I entered the last stretch of this disease. She told me that I was not, to wait for analyses, and that I had other options in case it was progressing again. But in the same breathe she reitareted that this cancer was an uncurable chronic disease, and that with chemotherapy on top of it, the rest of my life would be a bumpy road with ups and downs on how I feel and likely with with secondary ailments along the road. So it's not fun at all. Still alive, but with poor quality of life. I don't write that to complain, just to show the reality, and I am one of the lucky ones among the unlucky ones, because it is not a virulent cancer.