RE:RE:RE:Very I last few weeks, monthsThe efficient way to get us to a BLA is through the biomarker CelTiLs work and the identification of surrogate endpoints (ORR/PFS) that ONCY accomplished and presented as recently as this last week's ASCO 2024 meeting.
Title: Pelareorep driven blood TIL expansion in patients with pancreatic, breast and colon cancer.
Presentation Type: Online abstract
Abstract Number: e14625
Highlights from the abstract include:
The presence and expansion of TILs are associated with a better prognosis and response to treatment in cancer patients.
Pelareorep treatment increased TIL expansion in the blood in all pancreatic, breast, and colorectal cancer patients evaluated after one cycle of treatment.
Pre-existing TIL clonal expansion in the blood appears to correlate with tumor responses in pancreatic cancer patients.
The addition of the PD-L1 inhibitor avelumab, unlike atezolizumab, eliminated pre-existing TIL expansion in the blood and reduced pelareorep’s clinical activity.
These data suggest that pelareorep offers a simple, reliable way to expand TILs to provide clinical benefit.
https://oncolyticsbiotech.com/press_releases/oncolytics-presents-positive-updated-pancreatic-cancer-data-from-goblet-phase-1-2-study-at-esmo/