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A possible explanation for why BCG works for certain patients, fails in others and lacks a durable response may lie in the fact that BCG possesses a strong negative electrical charge. Cancer cells also possess a strong negative electrical charge. This results in the formation of a repulsion between the BCG bacterium and bladder cancer cells, which would thus make it difficult for BCG to adhere to and be absorbed by bladder cancer cells to affect a response. As a result, BCG remains unable to securely bind to the target bladder cancer cells and thus is ineffective in their destruction. This charge repulsion between BCG and bladder cancer cells is demonstrated clinically, by patients being required to undergo multiple BCG induction treatments,