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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > CD8+ TiLs and T-cell exhaustion
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Comment by Noteableon Aug 17, 2024 6:05pm
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Post# 36184478

RE:RE:RE:RE:RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustion

RE:RE:RE:RE:RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustionAs posted beforehand in this thread while immune checkpoint inhibition (ICI) therapy can be approximately 20-30% effective in a broad variety of tumors, resistance to ICIs arises from immune suppressive tumor microenvironments (TME).

This nothwithstanding,  pelareorp has demonstrated that it can generate a highly immune-infiltrated, inflammatory TME, that restores ICI responsiveness via recruitment, priming, and activation of anti-tumor T cells - and overcomes T cell resistance and T cell exhaustion - by enhancing the immune system for/with the sequential and synergistic addition of an ICI, such as Tecentriq or Keytruda, or another ICI, for example.
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