COSCIENS Biopharma Inc T.CSCI

Yeast-derived particulate beta-glucan induced angiogenesis..

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Perplexity Ai:

This research could have significant implications for Ceapro's yeast beta-glucan product:

1. Novel mechanism of action: The study demonstrates that yeast-derived β-glucan can induce angiogenesis through specific signaling pathways (PI3K/Src and ERK1/2). This provides a new understanding of how Ceapro's product may work at the molecular level.
2. Potential therapeutic applications: The angiogenic properties of β-glucan suggest it could be useful for conditions where increased blood vessel formation is beneficial, such as wound healing or tissue regeneration.
3. Cancer considerations: While angiogenesis can be beneficial in some contexts, it's also important in tumor growth. Ceapro would need to carefully consider this dual nature for any oncology-related applications.
4. Synergistic effects: The research shows β-glucan activates multiple pathways and receptors simultaneously. This could mean Ceapro's product has a more potent or comprehensive effect compared to compounds that target single pathways.
5. Differentiation from other sources: The study specifically looked at S. cerevisiae-derived β-glucan. If Ceapro uses this yeast species, it could potentially differentiate their product from β-glucans derived from other sources.
6. Research opportunities: This work opens up new avenues for further investigation into the specific mechanisms and effects of Ceapro's β-glucan product, potentially leading to new applications or improved formulations.
7. Regulatory implications: Understanding the precise mechanisms of action could be valuable for regulatory submissions and approvals, especially if Ceapro pursues any medical or therapeutic applications for their β-glucan.
8. Product development: Insights from this research could guide the development of new or optimized β-glucan products, potentially with enhanced angiogenic properties.

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Int J Biol Macromol

 

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. 2024 Jun;269(Pt 2):131884.

 doi: 10.1016/j.ijbiomac.2024.131884. Epub 2024 Apr 27.

Yeast-derived particulate beta-glucan induced angiogenesis via regulating PI3K/Src and ERK1/2 signaling pathway

Seung Min Lee 1, Jin Woo Lee 1, Jeongin Cho 1, Sujin Choi 1, Inki Kim 2, Chan-Gi Pack 3, Chang Hoon Ha 4

Affiliations Expand

• PMID: 38685541
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• DOI: 10.1016/j.ijbiomac.2024.131884

Abstract

The importance of β-glucan from S. cerevisiae in angiogenesis has not been well studied. We investigated whether β-glucan induces angiogenesis through PI3K/Src and ERK1/2 signaling pathway in HUVECs. We identified that β-glucan induced phosphorylation of PI3K, Src, Akt, eNOS, and ERK1/2. Subsequently, we found that this phosphorylation increased the viability of HUVECs. We also observed that stimulation of β-glucan promoted the activity of MEF2 and MEF2-dependent pro-angiogenic genes, including EGR2, EGR3, KLF2, and KLF4. Additionally, the role of β-glucan in angiogenesis was confirmed using in vitro and ex vivo experiments including cell migration, capillary-like tube formation and mouse aorta ring assays. To determine the effect of β-glucan on the PI3K/Akt/eNOS and ERK1/2 signaling pathway, PI3K inhibitor wortmannin and ERK1/2 inhibitor SCH772984 were used. Through the Matrigel plug assay, we confirmed that β-glucan significantly increased angiogenesis in vivo. Taken together, our study demonstrates that β-glucan promotes angiogenesis via through PI3K and ERK1/2 signaling pathway.