COSCIENS Biopharma Inc T.CSCI

Alternate Symbol(s): CSCI

Healthcare Biotechnology

COSCIENS Biopharma Inc., formerly Aeterna Zentaris Inc., is a specialty biopharmaceutical company engaged in the development and commercialization of a diverse portfolio of pharmaceutical and diagnostic products, including those focused on areas of unmet medical need. Its lead product, macimorelin (Macrilen; Ghryvelin), is an oral test indicated for the diagnosis of adult growth hormone deficiency (AGHD). The Company is also engaged in the development of therapeutic assets and proprietary extraction technology, which is applied to the production of active ingredients from renewable plant resources used in cosmeceutical products (i.e., oat beta glucan and avenanthramides, which are found in skincare product brands like Aveeno and Burt’s Bees formulations) and being developed as potential nutraceuticals and/or pharmaceuticals.

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COSCIENS Biopharma Inc

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Post by prophetoffactzon Aug 25, 2024 9:07am

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Post# 36195111

Wound healing: urgent requirement for healthy aging

Introduction

In 2015, the World Health Organization World Report on Aging and Health highlighted an urgent requirement for healthy aging strategies. The skin was identified as an area requiring greater attention with the aim of maintaining good health throughout the lifespan (

World Health Organization, 2015

). With increasing age, the skin undergoes changes in appearance and function, referred to as intrinsic or chronologic aging, and these are exaggerated by exposure to external factors such as UVR. In intrinsic aging, degradation and disorganization of collagen and elastic fibers in the dermis and at the dermalepidermal junction result in decreased skin elasticity and tensile strength (

Langton et al., 2016

;

Naylor et al., 2011

). Alongside this, deterioration of epidermal cellcell junctions contributes to greater skin fragility in the elderly (

Ghadially et al., 1995

). Cutaneous staphylococcal and streptococcal infections are frequent in the elderly owing to a decline in the skin’s barrier function and its immune capabilities (

Norman, 2003

); furthermore, wound healing is impaired, which exacerbates the risk of infection (

Gould et al., 2015