COSCIENS Biopharma Inc T.CSCI

GLP-1 & Oat-zempic

[prophetoffactz]

Gilles Gagnon commented on CZO's oat beta glucan pill clinical trial:

"...continued efforts may be warranted to explore its effect on weight and body-mass index with prolonged exposure and possibly higher dosage". 

While the weight loss effects were not statistically significant, the company views these preliminary findings as potentially promising and worthy of further investigation. 

Perplexity Ai:

Based on the research findings, oat beta-glucan appears to act as a natural stimulator of GLP-1 (glucagon-like peptide-1) release, though not as potently as synthetic GLP-1 agonist drugs like Ozempic (semaglutide). Here are the key points:

1. Oat beta-glucan is a type of dietary fiber found naturally in oats and barley.
2. Consuming beta-glucan can lead to increased production of short-chain fatty acids like butyrate in the gut.
3. Butyrate stimulates the release of GLP-1 from intestinal L cells.
4. GLP-1 is a hormone that helps suppress appetite, slow gastric emptying, and improve glucose control.
5. While oat beta-glucan can trigger natural GLP-1 release, its effects are much less potent than synthetic GLP-1 agonist drugs like Ozempic.
6. Studies have shown that beta-glucan consumption can lead to improvements in weight management, glucose control, and feelings of fullness, likely partly through this GLP-1 mechanism.
7. However, the "oat-zempic" trend of using oats as a substitute for Ozempic is considered "wildly overblown" by experts, as the effects are not comparable in magnitude.

In summary, oat beta-glucan can be considered a natural way to stimulate some GLP-1 release, but it is not a direct GLP-1 agonist like Ozempic. Its effects on weight and glucose control, while beneficial, are more modest than those of pharmaceutical GLP-1 agonists.