RE:AstraZeneca's ADC disappoints - on severe adverse eventsSeptember 13, 2024 - Daiichi Sanyo and AstraZeneca report positive results from the phase 3b/4 DESTINY-Breast12 study, which saw Enhertu chart substantial overall and intracranial clinical activity in a large clutch of patients with HER2-positive metastatic breast cancer who have brain metastases and received two or less lines of therapy in the metastatic setting. The data on the antibody-drug conjugate (ADC) were simultaneously published in Nature Medicine and presented as a late-breaking presentation at the 2024 meeting of the European Society for Medical Oncology (ESMO) Friday. The results won’t drive a new indication for Enhertu given that the drug’s current label doesn’t exclude patients with brain metastases. But data on those particular patients, which was previously limited, now add to a growing body of evidence around Enhertu’s merit.
On the trial’s primary progression-free survival (PFS) endpoint—which measures the time a patient lives without their disease getting worse—Enhertu yielded a 12-month PFS rate of 61.6% in patients with brain metastases at baseline, AZ and Daiichi said in a release.
https://www.fiercepharma.com/pharma/esmo-az-and-daiichi-sankyo-build-case-enhertu-breast-cancer-patients-whose-disease-has