RE:RE:Breast cancer treatment: perspectives on the oncolytic virusIn 2022, there were 2.3 million women diagnosed with breast cancer and 670 000 deaths globally.
https://www.who.int/news-room/fact-sheets/detail/breast-cancer
In 2024 approximately 310,720 women and 2,800 men will be diagnosed with invasive breast cancer in the United States.
There are currently more than 4 million women with a history of breast canacer in the United States. This includes women who are being treated and women who have finished treatment.
https://www.breastcancer.org/facts-statistics
In 2022, approximately 604,900 women were diagnosed with breast cancer in the WHO Europe region. Incidence in the EU-27 in 2022 was estimated to be 375,000
https://www.europadonna.org/breast-cancer/
Breast cancer is the most common cancer diagnosed in women in North America. Hormone receptor positive (HR+) and HER2 negative (HER2−) breast cancers account for at least 60% to 70% of all breast cancer.
cases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188964/
Consequently, based on 2022 numbers, approximately 685,700 women were diagnosed with invasive breast cancer just in the United States and the EU -27. With HR+/HER2 negative accounting for approximately 65% of all breast cancers - approximately 446,000 women will be diagnosed each year with HR+/HER2 negative breast cancer in the US and EU-27.
Out of the approximate 446,000 women newly diagnosed HR+/HER2 negative breast cancer each year, ONCY has estimated that approximately 55,000 of these women will progress to 3rd line mBC therapy which ONCY has stated will be eligible for pelareorep (monotherapy) + paclitaxel treatment.
An ASCO Meeting Abstract from the 2022 ASCO Annual Meeting has cited that the average cost for the first year of HR+/HER2 negative was US$192,367 per patient. With ONCY stating that approximately 55,000 women would become eligible for 3rd line pelareorep + paclitaxel treatment, and a per patient cost of US$192K, this patient group would translate into approximately US$10.56 Billion in annual sales for pelareorep in HR+/Her2 - mBC for ONCY or ONCY's Big Pharma acquirer.
https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.e18834