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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > Strategic Combinations: Future of OV therapy with reovirus
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Comment by Noteableon Oct 01, 2024 3:31pm
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Post# 36248892

RE:RE:RE:Strategic Combinations: Future of OV therapy with reovirus

RE:RE:RE:Strategic Combinations: Future of OV therapy with reovirusCrosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors

T-Cell Infiltration and Activation Within the TME Are Key Drivers of Anti-tumor Immune Response

[This work supports/confirms ONCY's TiLs clonality biomarker findings including that a major factor involved in initial resistance to immune checkpoint inhibitors is the lack or paucity of tumor T cell infiltration, characterizing the so-called “cold tumors” and that being able to identify patients with low levels of TiLs are those patients that positively response to ONCY's OV pelareorep + immune checkpoint inhibitors (ICIs) by ONCY's pelareorep being able to turn cold tumors "hot" thus priming the innate and adaptive immune system in advance of combining pelareorep with ICI therapy. ]
 

https://www.frontiersin.org/articles/10.3389/fcell.2021.738373/full 
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