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Oncolytics Biotech Inc ONCY


Primary Symbol: T.ONC

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > CD8+ TiLs and T-cell exhaustion
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Comment by Noteableon Oct 04, 2024 7:44pm
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Post# 36254108

RE:RE:RE:RE:RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustion

RE:RE:RE:RE:RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustionThe synergy of pelareorep + checkpoint inhibitors is with CPIs that have an inactived Fc region that was demonstrated with pelareorep with both Keytruda and Tecentriq. ONCY has posted this synergy in its PDAC and GOBLET-1 Phase 2 clinical trials. ONCY's BRACELET-1 Phase 2 mBC has demonstrated pelareorep's ability to be significantly statistic in clinically meaningful median overall survival as a single agent (monotherapy I/O agent) + paclitaxel in metastatic breast cancer.

Heineman clearly made that distinction in the recently issued and  below referenced and previously posted interview.

https://www.youtube.com/watch?v=QWqjcctuKP4
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