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Oncolytics Biotech Inc ONCY


Primary Symbol: T.ONC

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > CD8+ TiLs and T-cell exhaustion
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Comment by Noteableon Oct 14, 2024 1:04pm
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Post# 36265321

RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustion

RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustion
From ONCY's October 2024 slide deck: Slide #37

Why Did Avelumab Eliminate the Benefit of Pelareorep?

- Avelumab is the only licensed anti- PD-L1 Ab with a native Fc region that retains FcγR binding
 
- Hypothesis:
 
Binding of avelumab to Fc receptors impairs the expansion of T cell clones thereby diminishing the generation of potentially beneficial pelareorep-induced immune responses
- Possible Mechanisms:

(1) Avelumab binding to the FcγR on NK cells may induce ADCC-mediated killing of T cells
 
(2) Binding of avelumab to the FcγR on Avelumab TAMs may drive them to an immunosuppressive M2 phenotype 

(TAM = Tumor-associated macrophage)

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