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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > ONCY's pelareorep upregulates PD-(L)1 / PD-L2
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Comment by Noteableon Nov 01, 2024 2:43pm
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Post# 36292765

RE:RE:RE:ONCY's pelareorep upregulates PD-(L)1 / PD-L2

RE:RE:RE:ONCY's pelareorep upregulates PD-(L)1 / PD-L2Inside tumors, cancer stem cells can proliferate into new cancerous tissue. These cells are metastatic, resistant to chemotherapy, and extremely skilled at hiding from the immune system to avoid attack. “They are the root of the tumor,” said Bruno Sainz Jr., a molecular oncologist at the Sols-Morreale Biomedical Research Institute (IIBM) in Madrid Spain. “If you are able to attack and eliminate these cells, then you could potentially cure the cancer.” 

ONCY's has demonstrated that treatment of various cancers with intravenous administration of pelareorep upregulated levels of PD-L1, which are associated with high levels of tumor infilitrating lymphocytes (TiLs) and stem cell markers, resulting in the remodeling of a cancer's immunosupressive TME, and the reversal of those cancer cells growth and spread.
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