RE:RE:SABC 2024 - Irene Study Results - Pelareorep in TNBCDuring hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). ONCY's pelareorep down-regulates HIF-1α levels and in so doing remodels the tumor microenvironment (TME) for sequential immune checkpoint inhibition.