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Thiogenesis Therapeutics Corp V.TTI

Alternate Symbol(s):  TTIPF

Thiogenesis Therapeutics, Corp. is a Canada-based clinical-stage biopharmaceutical company. The Company is developing sulfur-containing prodrugs that act as precursors with the potential to treat serious pediatric diseases with unmet medical needs. The Company’s lead compound, TTI-0102, is a disulfide, made up of two thiols that lead to two independent cysteamine molecules. Cysteamine is a thiol that has been rigorously studied and tested. It is the active ingredient used in drugs to treat the lysosomal storage disease - (nephropathic) cystinosis. TTI-0102 has been developed to address the obstacles facing thiol-based drugs, their short half-life, gastrointestinal (GI) side effects and dosing limitations. As a prodrug, TTI-0102 is metabolized into cysteamine molecules after it is ingested. The metabolic process acts as a gating mechanism. TTI-0102’s initial applications are for MELAS, Leigh syndrome, Rett syndrome and pediatric non-alcoholic steatohepatitis (NASH).


TSXV:TTI - Post by User

Post by MarketMakersson Dec 02, 2024 4:00pm
35 Views
Post# 36341427

TTI Attains DTC Eligibility in the US

TTI Attains DTC Eligibility in the USLast week, clinical-stage biotech company Thiogenesis Therapeutics (TTI.v) announced attaining DTC eligibility in the US, facilitating electronic settlement of its common shares; a significant milestone aligning with the company's plans for a future U.S. listing.
 
As part of its U.S. listing strategy, TTI participated in the Capital Event Management (CEM) Conference in Miami from November 22-24, 2024, engaging with high-net-worth individuals, investment advisors, and institutional investors.
 
Thiogenesis' Market Opportunity
Targeting pediatric diseases with unmet medical needs and zero approved drugs or treatments, TTI is focused on developing novel thiol-based compounds to address mitochondrial dysfunction and its related diseases.
 
By focusing on diseases with high unmet medical needs, TTI is targeting a substantial addressable market as mitochondrial diseases collectively affect millions worldwide, with very few effective therapies currently available.
 
Representing a growing market segment in the pharmaceutical industry, estimates suggest the mitochondrial disease therapies market to be worth USD 1,817 million by 2030
(Source: https://www.rootsanalysis.com/reports/mitochondrial-disease-therapies-market-2019-2030/264.html?utm_source=chatgpt.com)
 
Lead Compound
TTI's lead compound, TTI-0102, is prodrug with an accelerated regulatory pathway that enhances intracellular cysteine levels. Notably, The compound demonstrated tolerance at significantly higher doses than previously approved cysteamine therapies in clinical studies, with sustained therapeutic levels allowing for potential once-daily dosing.
 
By leveraging its innovative compounds and focusing on pediatric diseases with no approved therapies, TTI has the potential to make significant strides in addressing critical gaps alongside addressing multiple indications within this growing market, presenting significant commercial and therapeutic opportunities.
 
Full News Release: https://www.newsfilecorp.com/release/231667/Thiogenesis-Announces-DTC-Eligibility-in-the-U.S.-and-Other-Updates
 
Posted on Behalf of Thiogenesis Therapeutics Corp.

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