RE:You ain't seen nuthin' yet - TLD1433 on Steroids in 2025....continued
too high a dose of deeply penetrating light along with too much photofrin uptake by healthy muscle cells had unacceptable results of bladder functionality.
This year Theralase will be moving on from intravesical to intravenous delivery of it's PS for gbm, lung and blood cancers and cancer cells will no longer have anywhere to hide. And for the first time Rutherrin is goung to be put to the test. The results of the coming trials should be much better than the the results of Theralase's currently successful NMIBC trial.
It has been known since 2015 how much more powerful
Rutherrin is than
TLD1433 by itself, especially in terms of selective uptake by cancer cells.
"Roger Dumoulin-White, President and CEO of Theralase stated that, “I am delighted that the Theralase scientific and research team has identified the potential mechanism of action of how our lead PDC TLD-1433 alone and when combined with transferrin to produce RutherrinTM is able to destroy cancer cells. By possessing the ability to enter a cancer cell, locate and attach to resident mitochondria and when light activated destroy the cancer cell, both TLD-1433 and RutherrinTM demonstrate a clear first mover advantage in the war on cancer, providing high efficacy with virtually no side effects. Based on the latest research RutherrinTM is able to provide 300% more payload of TLD-1433 to the cancer cell than TLD-1433 on its own. RutherrinTM, thus is a highly cytotoxic (cell killing) PDC, but because it kills the cell through apoptosis (natural cell death) it also presents an extremely high safety profile. The new discovery that TLD-1433 and RutherrinTM are also able to potentially act as diagnostic agents to detect cancer cells, provides the uro-oncologist with an additional tool of not only being able to detect resident cancer cells more easily and faster than traditional methods, but subsequently destroy them as well. This “one-two” punch to detect and destroy cancer has tremendous potential upside to Theralase, but more importantly to the patients inflicted with this deadly disease.” https://theralase.com/theralase-identifies-potential-mechanism-of-how-lead-anti-cancer-drug-works-to-destroy-cancer-and-discovers-new-application-to-detect-cancer-cells/