Just as excited about the Bacteria progress ! Tick Tock !TLD-1433 also is clinically used against several cancers [9]. Given its current usage and effectiveness against bacteria, we tested whether it also was effective against several human pathogenic viruses. We found that nanomolar concentrations of TLD-1433 were effective in inactivating >99 % of IAV, human CoV OC-43, Zika virus and herpes virus (Figs. 2 and 8). I
nactivation was very rapid; it required only seconds of exposure to light activation Hence, the viral inactivation mediated by TLD-1433-PDT-induced ROS is effective against different families of viruses, not only enveloped but also non-enveloped, via lipid peroxidation and potentially other mechanisms. Immune recognition structures appear to remain intact during this inactivation.
This opens potential opportunity to generate a broad spectrum of inactivated virus(es) vaccines with greater potency than vaccines pro duced by currently available inactivation techniques. Nanomolar_Concentrations_of_the_Photodynamic_Compo.pdf