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ProMIS Neurosciences Inc PMN

Healthcare Biotechnology
ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

ProMIS Neurosciences Inc > Cassava Drama
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Comment by M101on Jan 22, 2025 11:24am
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Post# 36415201

RE:Cassava Drama

RE:Cassava DramaI had a problem with their science presentation independent from the eventual fraud, the core hypothesis* was never fleshed out on the website as it is with Promis.   

*"Simufilam’s primary mechanism is to disrupt the toxic signaling of soluble Aβ42 via the α7nAChR that hyperphosphorylates tau"
https://www.mdpi.com/1422-0067/24/18/13927
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