Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe's Stomach-Friendly NSAID Keeps Chugging Along

[Free55dom]

Phase 3 trials in Canada before even the most preliminary toxicology studies are run in humans. But in this case, where a novel class of an analgesic/anti-inflammatory drug is sorely needed, whatever gets them there fastest is just fine. 

https://www.acsh.org/news/2021/03/31/antibes-stomach-friendly-nsaid-keeps-chugging-along-15442

[Marky1]

I sent Dan the article...This is his reply.....Nice PR; a lot of mistakes in it!

[Inthepez]

The biggest one is that otenaproxesul is not a pro-drug. That would denote that if take a handful of naproxen and a handful h2s, you’d get the same GI sparing effects. Obviously that’s not the case 

[Marky1]

I don't understand..Does the article say that otenaproxesul is a pro drug? I don't see that.. please clarify

[themagicbox]

Pez is correct. Josh Bloom had a link to one of his previous articles (here:https://www.acsh.org/news/2020/03/01/huge-advance-pain-management-nsaid-without-gi-side-effects-clinic-14606) Where he makes several mistakes in the chemical structure of the compound and calls it a pro-drug. Good eye, pez.

[RjM2018]

Inthepez - although Otena isn't a prodrug, your explanation of a prodrug  isn't incorrect. See Definition below. Ex: Vyvanse is a prodrug of adderall... Quote: "A pro-drug is a chemically modified structure of a known drug that is inactive until the active species is liberated by metabolism. ATB-346 is technically not a pro-drug since it breaks down to two active species

[Inthepez]

My explanation is directly taken from Wallace’s presentation in 2017: https://m.youtube.com/watch?v=w_3heP7ol0A