Antibe Therapeutics Inc(Pre-Merger) ATBPF

Time

[Lostchannel]

After viewing as much info, opinion etc I am taking a balanced view that this is still a great platform and will pay off. The real problem for retail investors is now the timeframe is extended.  Many have and will go away as the Sp will stay relatively flat now until at least they give the next update and likely for an extra yr??

[PlaySafe]

You forgot to mention that there is a new risk that wasn't there before namely, a new Phase 2 trial that needs to be statistically successful before they can even entertain going to Phase 3.  

[Inthepez]

Statistical significance is something ATE has been able excel at. The science/IP is the main thing ATE has going for it. Your fear mongering is sooooo transparent. FUD fairy alert 

[PlaySafe]

I agree that that the science needs to be there for the trial to work and we don't know yet if the drug is powerful enough at the lower dosage to work that is why they are re-doing the Phase 2 trial.  The other big component and uncertainty in a trial is the human component.  The participants are asked to evalute the effectiveness of the drug and if tthere is not a statistical

[themagicbox]

Wow this turd really  is fear mongering and strawmanning the arguments. Ok lets spell it out for this turd: 1- Pez never said they control statsitical signifcance, only that the science is so strong that it cant be denied statistically speaking. 2-The key takeaway from that Wallace video “translating h2s into therapies” is that you had very significant COX inhibition

[PlaySafe]

If what you say is true and Antibe knew and had all of this information then why did they not power the 150mg dose for statistical significance during Phase 2B.  Furthermore, I hear the words "unexpected results" as part of the AME PR.  So do you really think that they fully undestand what their drug is doing?  Furthermore, have you ever heard of the term "placebo

[WalkOverTheStrt]

Playsafe - placebo effect - google it and you'll see plenty of examples a recent one is Acasti's two PH3 trials (Trilogy) for Capre - it happens...

[PlaySafe]

WalkOver Street --- couldn't agree more, I owned Acasti and had high hopes for them.  So Antibe is going from a company ready to start Phase 3 to a company ready to re-do Phase 2 so now we need to pass two trials where placebo-effect could play a role versus only one trial.  Thus, grater risk.

[themagicbox]

Bro, you're desperate and grasping at straws. But I'll still put you in your place. Ph2 wasnt about finding the optimal dose it was about beating placebo. ph3 is about getting the doses correct. We BEAT the palcebo effect even at 150mg, and PK shows we'll beat it at 75mg equal to Naproxen at 500mg (from ph1 data). So i am not worried about beating the placebo effect even at 50mg. All

[PlaySafe]

First of all 150mg was not statistically powered in the Phase 2B trial so it did not show that it  statistacally beat placebo---get your facts straight.  Secondl, your argument is that PK shows that we will beat it at 75mg.  Do you even know what the placebo-effect is?  Based on your response you do not. The pleacebo-effect has nothing to do with the effectiveness or the

[themagicbox]

Oh man. The placebo effect occurs in the mind not the physiology. 75mg had COX inhibition equivalent to naproxen BID. Thats very compelling despite the placebo effect.  Thats why 150mg was so compelling despite not being power for satistical significance. You're very unlikely to have a statistical type 2 error. This is why the science matters and its not a flip of the coin issue. Nice

[CalgaryATE]

If you're worried about placebo effect, Stauffer was directly asked about it at Raymond James (June 23), you can hear his response and see if it assuage you. 26:40 - 29:00 minute mark of the following link (just checked and still works) https://kvgo.com/rj-health/antibe-therapeutics-inc-june-2021

[PlaySafe]

@Calgary ATE thanks for the link and I'm glad to see that Joe has a game plan to try and address the placebo-effect which in great to hear.  Fingers crossed that his placebo-effect strategy is effective and that the lower dose is statistically effective on a shorter duration Phase 2 trial.. Just to be clear, if Antibe proves that the lower dose is statistically effective as a primary