Wherever FDA approved chronic goes - it will be needed for all future chronic drugs too - and - it could circle back to future 20 year patents for pain as well. Never know.
- IBD will need a solution.
- Antiviral will need a solution.
A good thing is ...
There's a lot of opportunity in acute right now - general acute and very high pain acute. This will keep ATE busy for a while anyway.
In parallel, they will likely find a long term solution for ROS and I'm hoping ... it already exists with IBD - we're going to find out.
That's where I think specialty H2S releasing drugs are being developed which neutralize ROS. We've seen similar examples in development but only time will tell where ATE is going.
Hoping.
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example:
"
we developed a compound that reacts with O2.− to release a persulfide (RSSH), a type of reactive sulfur species related to the gasotransmitter hydrogen sulfide (H2S)" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719095/