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Bullboard - Stock Discussion Forum Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug,... see more

GREY:ATBPF - Post Discussion

Antibe Therapeutics Inc(Pre-Merger) > Question on interview
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Post by Doccole on Nov 24, 2022 8:36am

Question on interview

Dan reported that Antibe never saw the elevated liver enzymes in the animal studies and it wasn't until after it was discovered.

how does this new formation and new tests in animal studies rule out or support a reduced potency and lower enzymes?
Comment by StockingUp21 on Nov 24, 2022 10:21am
And in October these tests are not done. "We can" not "we have" we can capture the necessary data via a set of lower cost, de-risking animal studies    
Comment by MrMugsy on Nov 24, 2022 5:10pm
First - the acute trial is only 5 days (as per Dan). 2nd - dosing will be 2-4 fold less than we had. Liver enzyme is not an issue for acute. Also - 5 days is self-limiting and after 5 days, it's self-repairing. Wins all around. Risk has moved elsewhere. -------------------- Different story on the chronic side with 3 potential ways to market (as I see it).
Comment by Doccole on Nov 24, 2022 6:18pm
I look forward to being back in the trials.  Nice to see the zacks report.  Nice to see some inside buying.  More positive than usual.  let's pray this drug change is the one that makes the difference!
Comment by MrMugsy on Nov 24, 2022 6:57pm
Hahaha - wouldn't rely on prayer here. Focus on a deep understanding and an ability to pivot where/when needed. This is where the cash comes in useful ... to solve problems. I'm going to maintain that we needed the chronic problem to rear it's head ... so we could figure it out. Best we found it where we did rather than during P2 or P3-chronic. The AME was a perfect place - unfortunate ...more  
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