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Bullboard - Stock Discussion Forum biOasis Technologies Ord Shs BIOAF


Primary Symbol: V.BTI.H

Bioasis Technologies Inc. is a Canada-based biopharmaceutical company focused on research and development of technologies and products intended for the treatment of patients with nervous system, including central nervous system, diseases and disorders. The Company is engaged in the development of its xB 3 platform, which is a peptide-based technology, for the transport of therapeutic agents, in... see more

TSXV:BTI.H - Post Discussion

biOasis Technologies Ord Shs > Is There a Case Against xB3?
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Post by Boomskid on Jun 21, 2023 1:44pm

Is There a Case Against xB3?

I got an obscene inbox from craighenry this morning. Dispersed among the foul words were reminders from him that he has said for years that xB3 doesn’t work and that recent events prove it. He claims that he and his buddy regardless have always known that xB3 doesn’t work.

I won’t bother posting the names of all the others who claim that xB3 doesn’t work. They regularly do so in wild-eyed bursts here on Stockhouse, but they have no basis for the claim. They all speak with a certainty about Bioasis and xB3 that I cannot do. Neither they nor I have any proof or even evidence of a failure of xB3.
 
By “proof” I mean that, among other things, I can’t contradict the two scientific papers based on xB3 studies done at Texas Tech and by MedImmune/AstraZeneca. Those were peer reviewed papers detailing studies done by pharmaceutical professionals who must guard their reputations or they will be professionally destroyed in both academia and industry. And there were other papers and reported results from Canada’s National Research Council, UBC, B4B (Scarpa), and others, too many to bother looking up. They all reported success in the delivery of their payloads by xB3 across the BBB - job done by xB3. And remember, xB3 is not a therapeutic. It delivers a therapeutic payload across the BBB and that is its only job. 
 
None of the papers dealt with the worry I posted over two years ago about the off-target delivery of payloads to the LRP-1 receptors on normal brain cells. Longer-term studies are needed to show whether off-target delivery could develop into problems, but that would be an inherent part of any preclinical and clinical studies. That question would be resolved.
 
Dr. Deborah Rathjen has denied that any such problems exist with xB3.The other CEOs also deny any problems.

Even though Rathjen purposefully and publicly down-played xB3, she nevertheless was selling it to Midatech so she couldn’t very well allow LT, the placees, and Midatech to get all worried about the capabilities and value of xB3. The Midatech deal was all about xB3, make no mistake. How do we know? She was privately touting a deal with Ellipses for xB3-001, and yet she was not telling the public (shareholders) about it. It was put on public record. She was touting xB3, probably under NDAs, to the people who were buying Bioasis.
 
But then she accidentally leaked the Ellipses deal and lost or cancelled the deal. I suspect that once it was leaked the deal couldn’t be completed because it would show that Rathjen was PUBLICLY down-selling xB3 at the same time she was PRIVATELY touting xB3 to her suitors, LT, the placees and Midatech. (That is important and it ought to be investigated.)
 
It must also be recognized that Bioasis has done some business deals. They were done with industry professionals who are highly skeptical of new technologies. But Bioasis made the case for xB3 sufficiently that these companies paid a little money to Bioasis and used their own resources to do some work with xB3. I don’t recall that either the payloads or the targets were ever revealed in any of the deals, with the possible exception of Neuramedy with its rather obvious payload.
 
If any of all of those xB3 projects failed, there has been no indication that xB3 was the cause of the failures. It’s possible, maybe even probable, that the payloads failed in the CNS, which would happen after xB3 delivered them across the BBB and into the CNS. No company has ever reported that xB3 has failed, and they are unlikely to reveal that the payload, their own drug, has failed. There is no public evidence that xB3 licensed drugs have failured.
 
In the end there is lots of empirical evidence that xB3 works but no empirical evidence that it has failed. That’s a fact. So those who say that Bioasis’s woes are happening because xB3 has failed, that they always knew xB3 was no good, and that recent events have proved xB3 is no good, have no basis, whatsoever, to make the claim of xB3 failure.
 
So where does that leave us. craighenry, zwerp2000 and others are all spouting mindless blah blah blah. They are not aware that their statements about about xB3 failure make them look uninformed and quick to jump to unsupported (and unsupportable) conclusions. They, as always, destroy their credibility without being aware of it.
 
What I find interesting is that they can accuse me of all sorts of nefarious activities and yet they cannot believe that the failure of Bioasis could be because of the malice and/or incompetence of the company’s managements. I would think that those who are “in control” of the company would affect outcomes more likely than an opinion writer could.
 
There is no publicly known serious case against xB3. I think it likely that xB3 is OK and that lots of money will be made from it. 
 
jd
Comment by zwerp2000 on Jun 21, 2023 2:00pm
OMG! Get a life. Who cares>???? You really have nothing better to do with your time? It's so sad and pathetic that this board is basically your friend/family.
Comment by Boomskid on Jun 21, 2023 3:08pm
Oh, I understand, zwerp. You don't want me to comment about your comments about my comments about your comments about my comments about your comments about my comments about your comments. jd
Comment by prophetoffactz on Jun 21, 2023 3:23pm
xB3 has been given three management teams in addition to Medimmune, Prothena, Vaccinex, and Chiesi to find a path forward. There was Biodexa and Cresence. Many other companies have looked at xB3. It hasn't found an easy path forward in the least as DNLI continues to progess clinically. That said, there is nothing definitive saying that xB3 doesn't work that I'm aware of. DNLI's ...more  
Comment by beenthere on Jun 21, 2023 4:52pm
jd:   There is no publicly know serious case against xB3. I think it likely that xB3 is OK and that lots of money will be made from it. SO WHAT!  So what if you are right? Means NOTHING to us bag holders! And you DID notice the lack of discussion from our fellow bag holders?  NOTHING! Except from your haters. So the larger shareholders have given up and not willing ...more  
Comment by Boomskid on Jun 21, 2023 5:14pm
I do understand, beenthere, that you and many others don't understand why I'm posting and towards whom my posts are actually directed. But then, I wonder why you take the time to read them and to comment about them if they annoy you so much.  Ok. Thunderstorms coming. Gotta get out on my Thunder Walk. The goal today? 6 km in an average of 9 minutes and 30 seconds per km, or better. ...more  
Comment by beenthere on Jun 21, 2023 6:55pm
Doesn't matter who they are directed at! They don't care about your opinion and I sure wished I hadn't! But that's water until the bridge now isn't it? As for walking good for you. Myself I use to do a 10k walk per day and never missed a day. Then 3 years next month  that went all to hell with a stroke. None of that anymore but still consider myself lucky because I ...more  
Comment by Boomskid on Jun 21, 2023 6:58pm
Yeah, they care, beenthere. Your opinion doesn't matter on this one. jd
Comment by beenthere on Jun 21, 2023 7:20pm
... so they care ..... ....what the hell does  that mean?  .... still hope?? ... doubt it!
Comment by beenthere on Jun 21, 2023 7:21pm
..for me.... I am going back to buying 649 ... I feel I have the same chance!