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Bullboard - Stock Discussion Forum Algernon Pharmaceuticals Inc. C.AGN

Alternate Symbol(s):  AGNPF

Algernon Pharmaceuticals Inc. is a clinical-stage drug development company. The Company is focused on developing repurposed therapeutic drugs in the areas of non-alcoholic steatohepatitis (NASH), a type of liver disease, chronic kidney disease (CKD), inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF) and chronic cough as well as advancing a stroke program using N, N... see more

CSE:AGN - Post Discussion

Algernon Pharmaceuticals Inc. > Except from article:Additionally, AT7519 and ifenprodil
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Post by Cookie2018 on Apr 04, 2021 9:03pm

Except from article:Additionally, AT7519 and ifenprodil

"Additionally, AT7519 and ifenprodil, which showed slightly lower vRNA-level reduction, were included due to their distinct binding sites outside of the active site. From these eleven, seven compounds (AT7519, calpeptin, ifenprodil, MUT056399, pelitinib, tolperisone, triglycidyl isocyanurate) exhibited at least one hundredfold reduction in infectious particles in combination with either selectivity indices (SI = CC50 / EC50) greater than five or no cytotoxicity in the tested concentration range and are considered antivirally active (table S5)."


Full Article:-

https://science.sciencemag.org/content/early/2021/03/31/science.abf7945
Comment by Cookie2018 on Apr 04, 2021 9:09pm
Key statement:- reduction in infectious particles less is less, not more, so it is doing what it was intended to do....