Post by
Cookie2018 on Apr 04, 2021 9:03pm
Except from article:Additionally, AT7519 and ifenprodil
"Additionally, AT7519 and ifenprodil, which showed slightly lower vRNA-level reduction, were included due to their distinct binding sites outside of the active site. From these eleven, seven compounds (AT7519, calpeptin, ifenprodil, MUT056399, pelitinib, tolperisone, triglycidyl isocyanurate) exhibited at least one hundredfold reduction in infectious particles in combination with either selectivity indices (SI = CC50 / EC50) greater than five or no cytotoxicity in the tested concentration range and are considered antivirally active (table S5)."
Full Article:-
https://science.sciencemag.org/content/early/2021/03/31/science.abf7945
Comment by
Cookie2018 on Apr 04, 2021 9:09pm
Key statement:- reduction in infectious particles less is less, not more, so it is doing what it was intended to do....