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Bullboard - Stock Discussion Forum Oncolytics Biotech Inc ONCY


Primary Symbol: T.ONC

Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and... see more

TSX:ONC - Post Discussion

Oncolytics Biotech Inc > GSK drops the development of engineered cell therapy
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Post by Noteable on Oct 25, 2022 12:55pm

GSK drops the development of engineered cell therapy

This development further places ONCY in a favourable position as pelareorep is able to remodel the tumor microenvironment and enhance T-cell clonality, and thus mitigating T-cell exhaustion, particularly when pelareorep is combined with an immune checkpoint inhibitor.

https://www.evaluate.com/vantage/articles/news/deals/gsk-deals-cell-therapy-another-setback
Comment by Noteable on Oct 25, 2022 12:58pm
October 25, 2022 - GSK is trimming back in cancer cell therapy research, disclosing plans to end partnerships with Lyell Immunopharma and Adaptimmune that were intended to develop immunotherapies for solid tumors. https://www.biopharmadive.com/news/gsk-terminates-lyell-adaptimmune-cell-therapy-deals/634900/
Comment by Noteable on Oct 26, 2022 11:54am
October 26, 2022 - GSK has terminated its NY-ESO-1 T-cell receptor (TCR) pact with Lyell Immunopharma, with the Big Pharma transferring the program to Adaptimmune.  The winner from this decision appears to be Adaptimmune, which announced in a separate release today that it had gained possession of NY-ESO and another TCR T-cell program called PRAME. The ...more  
Comment by Noteable on Oct 27, 2022 12:32pm
October 27, 2022 - Bluebird spinout 2seventybio and China-based CAR-T company JW Therapeutics collaborate to build out a cell therapy platform with the aim of developing T cell receptor (TCR) therapies for solid tumors.  2seventy bio secured its legacy in the cell therapy arena by developing FDA-approved CAR-T Abecma with Bristol Myers. Meanwhile, JW Therapeutics has achieved cell ...more  
Comment by Noteable on Nov 02, 2022 4:54pm
November 01, 2022 - GSK's looming Zantac lawsuits raise doubts on the company's immediate M&A activities - as Wolfe Research analyst Tim Anderson suggested during a separate earnings call with investors. The uncertainty around the Zantac lawsuits means GSK might have to reserve money to resolve the legal liabilities. That could mean a temporary hold on dealmaking, especially ...more  
Comment by Noteable on Nov 09, 2022 12:53pm
November 09, 2022 - GSK's engineered cell therapy world continues to collapse - this time on the news on Adaptimmune's allogeneic cell therapy program change as reported below today. "Adaptimmune’s allogeneic MAGE-A4 program seemed to be near the finish line, with the company’s UK manufacturing facility almost done. The plan at the time was for the cell therapy to be ready for ...more  
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