ProMIS Neurosciences Inc PMN

PMN 310 Clinical Trial

[bball67]

Sorry, but I don't care about Acumen's two year delayed Phase 1 clinical trial on 62 patients. It has provided no read outs. 

PMN 310's IND apllication will be made in December. After 30 days it will automatically be approved with no FDA letter. So, Promis will be dosing in January or February 2023. 3 months of placebo control  to assess ARIA-E, brain bleeding risk. Then a nine month period where doses are ramped from 2.5 to 60 mg. I don't believe any previous ALZ climical trial, got anywhere near a 60 mg dose. Oh, and by the way Promis will be releasing blood biomarker readouts for 5 different ALZ biomarkers.Never done before. Promis has developed a proprietary biomarker test. Every month there will be readouts in an "open label trial". This is a bold move in my opinion, and there will be a lot of attention on these readouts. I believe they are calling this 1b of the phase 1 trial. Promis has previously asserted that this proposed clinical trial structure may accomplish Phase 1 and 2 goals. The fact that they have indicated they may do another financing in the phase 1b trial, indicates to me that they anticipate positive biomarker results that indicate that PMN 310 is having a significant impact.. It is even possible, that PMN 310 may be reversing the disease. See page 23 of the  corporate presentation.

[G1945V]

"See page 23 of the corporate presentation. " ball67.......Which presentation is this? Can you please link it up? G1945V

[BottomBroker]

https://www.promisneurosciences.com/news-media/corporate-presentations

[FarmerBetty]

Yes, bball you did care before when Acumen was on Promis's corporate presentations for months. They don't look a like a fly by company had 210 million in cash at the end of June. Actual study start June 2021 first patient dose October 2021. BBall you are saying PMN making IND application in December, 30 day approval, dosing to begin in January or Feburary? Really quite incredible for

[bball67]

Farmer, you don't think they forgot all about getting people to participate in a trial do you? You seem to think they can't recruit people to participate until they file IND, where did you get that? I think that is wrong. You ask potential patients "are you willing to participate in a potential clinical trial of an Alzheimer's drug". Would you be surprised if the Company has

[retiredcop]

First doses of PMN310 will be the safety phase and these doses will be adminstrated to healthy people.. it was mentioned that in most clinical trials , these first group of indiviauls are post secondary students and alot of them are med students . They are paid very well for their participation... If there is anyone else that sat in on the meeting with the new CEO and Dr Cashman could correct me