Spectral Medical Inc T.EDT

Alteco...

[mercedesman]

A Swedish Company with an Endotoxin Absorber...is not afraid to talk about it.

they are even using our EAA!!

Since Oct 2019 to today , their stock is up 40%

Spectral's stock is down 50% during the same time period.



https://altecomed.com/covid-19/

Is there a rationale for endotoxin removal in severely ill COVID-19 patients? As a matter of fact, 90% of patients with severe pulmonary forms of COVID-19 have increased endotoxin levels and the level of endotoxin is directly related to the severity of COVID-19.  Also, these patients are at high risk of sepsis.

Endotoxin triggers cytokine storms

The spike protein in SARS-CoV-2 has been shown to bind to endotoxin, starting the inflammatory signalling and dysregulated immune response.  Endotoxin is one of the most potent bacterial inducers of cytokines and can induce a cytokine storm through binding to Toll-like receptor 4 (TLR4).

High risk and prevalence of bacterial infections

Dysregulation of the immune system may be associated with a high risk of developing a secondary bacterial infection. Studies show that up to 60% of COVID-19 patients in the ICU have secondary bacterial infections – most commonly respiratory infections from gram-negative bacteria. 

COVID-19 patients with pulmonary superinfections require longer ICU-treatments  and are at higher risk of ventilator-associated pneumonia (VAP)  – in fact, it is the most frequent hospital acquired infection in these patients, and it is often caused by gram-negative bacteria. Furthermore, VAP has been demonstrated to be the most frequent hospital infection associated with septic shock.

In the absence of a bacterial infection, antibiotic treatment can cause release of endotoxin, triggering endotoxemia and over-production of pro-inflammatory cytokines – an antibiotic-induced inflammatory storm. 

Translocation of bacteria from the gutEndotoxin in COVID-19 does not originate from the virus itself but is thought to be released from gram-negative bacteria in the gut, due to inadequate blood flow.  The gut barrier dysfunction that allows endotoxin to leak out from the gut into the blood, can potentially cause sepsis and multiple organ failure.  Also, it can travel to the lungs and affect the immune response as well as the lung microbial composition.

 

 

Endotoxin removal in COVID-19 – conclusion

Extracorporeal techniques have a possible role in “restoring a balanced immune response by eliminating/deactivating inflammatory mediators”.  Binding and clearing endotoxins from circulation could be an appropriate intervention in the fight against COVID-19.

Studies have shown that endotoxin adsorbtion results in clinical improvement in severe COVID-19 patients with elevated endotoxin levels (measured by EAA, Endotoxin Activity Assay).  The Alteco LPS Adsorber removes endotoxin (lipopolysaccharide, LPS) from the patient’s blood as it passes through the device. Based on the significance of endotoxin in COVID-19, the Alteco LPS Adsorber may be of use in COVID-19 patients suspected to have gram-negative bacterial infection, signs of inflammatory response, endotoxemia or sepsis.  The removal of endotoxin turns down the exacerbated immune response, helping to stabilize the patient’s hemodynamic parameters. 

 

 

[daviking]

So are you saying there is a competitor to EDT with the ability to remove endotoxin?

[oilandgasman]

https://clinicaltrials.gov/ct2/show/NCT02335723

[oilandgasman]

https://www.presepsintest.ru/upload/iblock/a8d/a8d042bcbec3ac2a3818a9ec68d4816d.pdf

[daviking]

Thanks OGM Study completed 4 years ago and I can't figure out what the results were! I take it that it wasn't significant enough to start a Phase one trial. Oops, relooked and saw it was terminated. Couldn't find enough subjects - Where have we seen that before?after?