Oncolytics Biotech Inc T.ONC

Next Gen antibodies seeking to mimic Pelareorep + ICI action

[Noteable]

Next-generation multi-specific antibodies, which target multiple antigens or epitopes on the same antigen, seek design to target multiple cells in the tumour microenvironment, rather than a singular molecular pathway, just as ONCY's multifunctional pelareorep is capable of doing. 

The next generation anitbodies aim to influence tumour death through various mechanisms including T cell costimulation, engagement of innate and adaptive immune cells, inhibition of specific mutation-driven signalling pathways, blockade of immune checkpoints, and targeting multiple antigens to increase tumour selectivity, just like ONCY's pelareorep in combination with immune checkpoint inhibitors are capable of achieving.

Furthermore, with the understanding of complex interactions between tumour and immune cells in the TME advances, it is likely we will identify new targets and immune signatures specific to certain cancer types and individuals.

Cancer treatment is inexorably becoming more personalised, and, one day, it may be possible that IO therapy combinations can be routinely tailored for patients based on their specific immune signature.

 

[Noteable]

I would further propose that this development is another reason why ONCY is worth north of US$ 8 Billion, since it is becoming increasingly evident that Big Pharma is seeking multifunctional assets like ONCY's pelareorep that can address the complex interactions between the tumor and the TME - both by engaging the innate / adaptive immune system and modulating the TME in advance of immune

[Lesalpes29]

u If we see a buyout at this price, I will ski in Les Alpes next winter! Of course I will be retired too!

[Capitalista]

Lesalpes29, I may see you there!.  I'm going regardless of ONC's fortunes, as YOLO.  Mribel is my chosen venue.   

[Lesalpes29]

Meribel, nice for you. Been in Chamonix once. Not able to get back there. It was 20 years ago, time goes fast.

[Buckhenry]

I will sell my many shares at a discounted price of 6B to the first person that's responds. please send cash... blue skies