Oncolytics Biotech Inc T.ONC

Pfizer pivots to 'externalization" of rare disease programs

[Noteable]

January 06, 2023 - Pfizer is stepping back from early-stage rare disease R&D and has begun “exploring externalization opportunities for a number of highly innovative, niche programs” as part of a rethink of its approach to orphan indications.

The company said it would "externalize" most of its early-stage rare disease programs in neurology and cardiology, and gene therapy programs not yet in clinical trials.

Pfizer will continue to develop viral vector-based gene therapies for hemophilia A, hemophilia B and Duchenne muscular dystrophy, according to Barron’s, while shifting its investment to other delivery vehicles such as lipid nanoparticles (LNPs). 

“This approach will allow us to focus on programs where our innovation and investments are differentiated and where we are best positioned to generate high-impact medicines and vaccines" according to a Pfizer spokesperson

Pfizer’s current gene therapy portfolio includes three late-stage clinical programs for hemophilia A, hemophilia B, and Duchenne muscular dystrophy (DMD), as well as 12 preclinical programs investigating potential treatments for rare cardiology, endocrine, hematology, metabolic and neurology diseases.

https://www.fiercebiotech.com/biotech/pfizer-pivots-early-stage-rare-disease-rd-shifting-external-innovation-and-putting-assets

[Noteable]

“This approach will allow us to focus on programs where our innovation and investments are differentiated and where we are best positioned to generate high-impact medicines and vaccines"  - sounds like Pfizer is seeking to differentiate their investment into a company like ONCY with a high impact medicine in the treatment of multiple cancers. 

[westcoast1000]

Let us hope they appreciate ONCY and pela as much as we think they should, Noteable. All indications point in that direction. But it is a lot to expect and hope for. 

[Noteable]

westcoast - In August ONCY reported that :  "Clinical biomarker data show pelareorep remodeling tumor microenvironments to improve prognosis and decrease the risk of recurrence in HR+/HER2- breast cancer patients"  With ONCY reporting that pelareorep clinical data was demonstrating pelareorep's ability to remodel the TME and also knowing NOW that both the TME and an

[Noteable]

ONCY also reprted that :  "In the GOBLET trial's pancreatic cancer cohort ... objective responses suggested pelareorep's clinically demonstrated synergy with checkpoint inhibition in breast cancer extends into additional difficult-to-treat indications. Together, these findings further position pelareorep as an immune platform molecule that can enhance the efficacy of a variety of

[westcoast1000]

Thanks, Noteable. I agree with you completely.

[Buckhenry]

you baby pumpers are sucking the hind tit on unnoteable... u believe everything he says ... hook.. line.. and sinker...

[TitanBrawler]

This post has been removed in accordance with Community Policy

[TMAZZ21]

Buckhenry, one of your first post only 5 months ago see below dated August 5th 2022, where your talking 5-50B and now all your doing is bashing??? What gives? What's your motive? how do you go from 5-50B five months ago to ATM today? Looks like your perception is the only thing that has changed nothing else.   Your either continuing to accumulate cheap or cheaper shares with your

[Lesalpes29]

Hahaha! Fuchenburry!

[Buckhenry]

This post has been removed in accordance with Community Policy

[Buckhenry]

credibility on an online site... your delusional...this is an entertainment site. now one has any credibility on any online site. 

[canadafan]

I get all of my points from Onc web and/or public news reports. very credible  speaking of which, Onc has just released a new " investor presentation" covers the points very well. As I mentioned look up Ad Hominem...that is you Buck onecstep above school yard name calling. You saying nothing in here has any credibility, certainly does not make it so. especially when most of not all

[inthno]

Good post Canada and have a question just in case you might know. Nice to see the insiders holding that many shares. Out of curiosity do you have any idea how many of those shares they may have actually bought on the open market and not as part of compensation. I am still looking for something big to happen by at least the AGM so here's hoping for the best and should be our time as ONC has

[fox7mf]

It's been established for quite sometime that Buck only spews moronic, self serving, bashing pablum, so why even reference him/her? He/she was only on pt once when it stated the future valuation of Onc could be $50b;) Let's talk about the 90 day exclusivity that is about to end. Let's talk about the pressure on PFE to table an offer. Maybe news this week from the  JP Morgan

[Normandt]

I agree with Fox7mf. These morons have corrupted the yahoo forum to the core, the admins included. Don't let them do the same here. Ignoreland.

[Buckhenry]

why haven't you used the ignore dufus... I think you enjoy it deep down in this entertainment site. 

[Buckhenry]

again... you can block anytime you want so shut up dufus

[Buckhenry]

unnoteable must be on the payroll and gets paid by the number of posts he spews out. 

[Noteable]

You ask ... and I respond with facts.

[Angler101]

Shmuckhenry.......what’s your problem with Noteable....he consistently provides valuable info to this board, and out of over 200 posts here, you’ve never once EVER provided any.....it’s obvious who’s really the one getting paid to post...

[Buckhenry]

unnoteable just keeps regurgitating and posting the same ole sh!t. maybe its valyeable for you folks that dont do ur own research. and its still a free site to post what you want .... sorry if you dont like it. maybe you need therapy to cope... either way I dont give a dime.