Oncolytics Biotech Inc T.ONC

keep the enthusiasm in check

[inthno]

Yes we have had a great trial with the panc. But did anyone ever compare it to cornerstone pharmaceticals which had better results in their phase 1 trial than onc and then failed in their phase 3 trial. They actually had 3 cr's in their 20 patient orginal study, were allowed fast track but not AA....As Much as we all want this to work we need to understand that there is no guarantee and as much as I would like to see this partnered I would really prefer a buyout so as to not have to take a chance with the followup trial that might not prove out. I said before that 2 billion is reasonable considering all the risks that are still associated with future trials and really wonder if onc has ever been offered something similar and turned it down hoping for more. Just being a realist as the result and company comparisons so far are very similar.

[Noteable]

inthno - "NO" $2 Blillion is "not" reasonable given that ONCY has "de-risked" pelareorep beyond, for example, those companies that were acquired for  US$2-4 Billion who were only in the pre-clinical stage of development which I have listed as examples in multiple messages beforehand. For whatever reason, you seem to be conveniently forgetting those "risk-on

[westcoast1000]

Good points inthno.

[Noteable]

Nonsense.

[inthno]

Not nonsense as the results of the cornerstone trials cannot be disputed. My main point is that if onc is in negotiations that would it not make sense to sell at a resonable price and remove all doubt for all of the shareholders especially the lifers than to take a CHANCE in the phase 3 while waitng 2-3 more years. You know the saying bird in the hand. As much as we think we are derisked there is

[Noteable]

Complete nonsense.  A "one-trial" is the quickest path to full approval and completely de-risks the product development process. And this acheivement comes with an absolute M&A premium. Furthermore ONCY's would be employing biomarker defined cohorts of patients which further de-risks the clinical trial

[inthno]

Yes the quickest path to full approval but not guaranteed no matter what you say. So you are suggesting to all of the people that follow you that if a 2 billion offer was put forward to shareholders , a guaranteed sale and money in their pocket that you would reccommend that we all turn the offer down. Nothing personal and as much as I do appreciate some of your posts, you are not nearly as savey

[askretka]

That drug your referring to was combined with FOLFIRINOX in latest trial a much more toxic drug than what Pelareorep is combining with and requires a ECOG of 0 or 1. -------------------------------------- If you remember KOL the panel they said that they would have no problem putting patients of ECOG of 2 in the trial with pelareorep because of the excellent safety profile.  We're going

[Lesalpes29]

Keep posting here to have a balance point of vue. We have a product not good enough to be used alone. We are the little dog who needs a big dog with a proven product to have value. Less then 80 millions of market cap and almost no interest by buyers actually. Hope management will have a big NR to get the interest back. GL

[westcoast1000]

Our virus may not be powerful ennough to kill enough cancer to be effective on its own. But it is very good in a LOT of indications and with a lot of other I/O agents by engaging the immune system. That more than makes up for the inability to work as a monotherapy. 

[Capitalista]

I agree, WC1000.  Combination therapies seem to be emerging as the way to go in immunotherapy - there is no "killer app" available yet in this research field.   The difference in overall response between combo therapies using Pela and those not (i.e. control arms) is what gives me hope.  I'm still waiting for ONC management to get Pela approved and monetize it.

[Lesalpes29]

Agree with both of you. Now what is the real value of a drug that could be used in many indications and in a mix of many? We will see I hope. GL

[Buckhenry]

we must be in a time warp here.... I swear I have heard all the same posts 3 years ago....  kickin the can do an the road....