Oncolytics Biotech Inc T.ONC

crosstalk between senescent cells and CD8 T cell-dependent a

[Noteable]

The ability of ONCY's pelareorep to stimulate crosstalk in the TME has been attributed to pelareorep's further ability to stimulate the innate and adaptive immune system and prevent T cell loss/exhaustion that has been seen with long term PD-1 monoclonal antibody treatment.

April 04, 2023  - https://www.nature.com/articles/s41514-023-00105-5.pdf

In line with this finding, long-term administration of anti-PD-1 monoclonal antibodies enhances CD8 T cell-dependent clearance of p16+ senescent cells and alleviates the pathological sequelae linked to the overabundance of senescent cells in contexts of natural aging and steatohepatitis.

[Noteable]

ONCY's pelareorep (reovirus) capabiltiy of remodeling an immunosuppressive / hypoxic tumor microenvironment (TME) results in the ability upregulating of turning "cold" tumors into "hot" tumors  through innate and adaptive immune responses to treat a variety of cancers, and overcoming the issue of T-Cell exhaustion through clonal proliferation of T-cell and the

[Noteable]

Once again -- should read: "...results in the ability of turning "cold" tumors into "hot" tumors  .. through innate and adaptive immune responses to treat a variety of cancers, and overcoming the issue of T-Cell exhaustion ... "