Post by
Journeytc on May 09, 2024 10:57am
Todays Announcement Goblet Expansion
Pure specilation on my part. GOBLET achieved magnificent result in the GOBLET pancreatic trial with the pela ICI combo. So why fuss with success and expand Goblet to include Folfirinix +- ICI? High cost might limit access to treatment, limit who can be saved and reduce treatment population size. And treatment population size affects earnings. Pancreatic cancer is a much smaller indication tham breast and if population is further reduced on cost thats a problem. Im guessing treatment costs would be 300,000 us dollars per patient. 150,000 dollars for pela and 150,000 dollars for ICI.
If ONC with biomarker, can identify a large sub group within the population responding to the combo treatment, thats a big deal for patients, for cost and safety. And i think its portends whats to come for pela in the treatment of all sorts of different cancer indications.
Todays announcement is great especially sonce effort is sponsored by someone else.
Comment by
Noteable on May 09, 2024 11:07am
All the "fuss" is about gaining a larger/bigger market share of pancreatic cancer market by being able to initate treatment both in the early and advanced stages through the treatment of both older and younger patients.
Comment by
Noteable on May 09, 2024 11:52am
Tell my why CADL is worth US$10 when they only have Phase 2 results in 13 patients using intratumorally injected herpes virus in patients with non-metastatic borderline resectable pancreatic cancer.
Comment by
Peladawn on May 09, 2024 12:19pm
Note....whatever their sp is right now, the good news is that a month ago it was only $1.58....that's how quickly it can and does change.....
Comment by
Noteable on May 09, 2024 12:34pm
A very weak answer to my question, since CADL is up to around US11 on very little comparable news to ONCY, I won't go into the other reasons why ... since my question was rhetorical in its very nature.
Comment by
Noteable on May 09, 2024 1:11pm
Go try your bait somewhere else.
Comment by
Angler101 on May 09, 2024 1:16pm
bait, what bait?....I simply would like you to cut and paste proof that Trump is guilty of insurrection, considering you seemingly have no problem accusing him of it...otherwise, that alone sets you up for a defammation lawsuit...
Comment by
Noteable on May 09, 2024 1:21pm
Angler101 - do you have a good lawyer, you will need one.
Comment by
Peladawn on May 09, 2024 1:25pm
Why would I need a lawyer?......tell me exactly what I have done to you, that you haven't done to Donald Trump!
Comment by
Peladawn on May 09, 2024 1:28pm
All you have to do is cut and paste proof that Trump is guilty of insurrection, and I will apologize for making a point and we can call it a day!
Comment by
Noteable on May 09, 2024 1:29pm
Well isn't that interesting ...now we see that Angler101 is also Peladawn.
Comment by
Peladawn on May 09, 2024 1:33pm
This post has been removed in accordance with Community Policy
Comment by
13X2413 on May 09, 2024 1:57pm
OMG. Move on. Focus! ONC showing some life. Stop fighting kids or you'll have to go sit in a corner.
Comment by
Buckhenry on May 09, 2024 2:16pm
The pumpers trying to move focus elsewhere and talk about things they know even less about cause nothing is going on with this dud.
Comment by
Azzak34 on May 09, 2024 2:17pm
Shut up Buck, let them scrap it out. Don't be a lil beeatch on the sidelines.
Comment by
Buckhenry on May 09, 2024 2:25pm
Wonder who MC is in collusion with???
Comment by
Azzak34 on May 09, 2024 2:33pm
Your mum. Colludes every Friday at the Motel 6 down the road from you.
Comment by
Buckhenry on May 09, 2024 3:12pm
What about unnoteables cult following.... cults don't generally end well.
Comment by
Peladawn on May 09, 2024 2:01pm
Gee, what a surprise!...still no proof of insurrection.....or Russian collusion....always ready to repeat the false accusations, but never the slightest hint of proof....
Comment by
Peladawn on May 09, 2024 2:20pm
Yeah....just like all the "dazzling" proof that pencil neck Adam Schiff lied to the Senate and the American people about for four years about how Trump "colluded" with Russia to overthrow the election, and still to this day he hasn't managed to come up with a shred of proof.
Comment by
Noteable on May 09, 2024 3:07pm
My goodness Trump's Cult is dangerous in their loyalty to him as a person. Very much like other cult members in autocratic dictatorships like Russia, China, and N. Korea - which Trump especially likes.- Poland, Turkey, India, Brazil, Chile, Argentina, etc.
Comment by
Noteable on May 09, 2024 3:18pm
I'm sorry but Peladawn, but that how democracy works. Those like Marjorie Taylor Green could have become part of the Bipartisan Select Committee but she and other Trump Cult members refused. Now most others of the Republic Party are having different thoughts about their boycott, including Mitch McConnell and former Republic Speakers of the House..
Comment by
Noteable on May 09, 2024 3:22pm
It took courage for many Republicans to oppose Trump's Cult. Unfortunately not many Republicans have that sort of fortitude and instead just " fall into line" with their power hungry loyalty.
Comment by
Peladawn on May 09, 2024 4:16pm
Bang on CMH!.....I agree 100% with everything you said.....don't even try to convince Notable....easy to see he's way too far gone....sometimes Trump Derangement Syndrome can progress to a permanent condition...... hey, let's get together later for some Yoga and meditation,.....lol!
Comment by
Noteable on May 09, 2024 4:23pm
If you Peladawn aka Angler don't like to read what I say then that just further proves your closed minded Cult membership.
Comment by
Peladawn on May 09, 2024 4:27pm
See what I mean, CMH?.....WAY too far gone!
Comment by
Buckhenry on May 09, 2024 4:27pm
Finally.. Unnoteable talking about something he knows a little about.... very little.
Comment by
Buckhenry on May 09, 2024 5:28pm
These pumpers sure don't like anyone pouring water on their woke narrative fire here. We should all love and accept each other's views... you know that's what DEI is all about... pukes here...
Comment by
Azzak34 on May 09, 2024 5:35pm
Bahahaha Bucky gettin in on the policital action!!! Give us more Dumper, what's your take on the geopolitical outlook for us all? Everyone sit back and relax, Bucktard is gonna fix it all...... go Buck.
Comment by
Peladawn on May 09, 2024 5:48pm
Yehaaaaa!......go Buckster!....
Comment by
Buckhenry on May 09, 2024 5:51pm
The pumpers definition of DEI is Division Exclusion..and Intrusion...
Comment by
Azzak34 on May 09, 2024 5:54pm
Thats some powerful stuff there Buckster. Kay, now do BDS. What's the pumpers definition of that?
Comment by
Peladawn on May 09, 2024 5:55pm
Well, Bucky, you should know all about intrusion.
Comment by
ENEMENEMYNEMO on May 09, 2024 6:41pm
Wow. Blown away by the news! Three "potential " phase 3 studies but no cash to pay for it and no partners. Lookin pretty rosie guys!
Comment by
Peladawn on May 09, 2024 7:22pm
Yeah, that's exactly right, EMEMEmo buana bimo.......we've had nothing but positive trial news....so it only stands to reason how no big pharma could ever possibly be interested in joining Up somehow!
Comment by
Noteable on May 09, 2024 1:13pm
Angler101 - Are you trying to falsely accuse me of feloney tax evasion. If so, you better get a good lawyer!!
Comment by
Angler101 on May 09, 2024 1:20pm
What's the matter, Note, ol' boy?....you have a problem with being falsely accused?....well, then, maybe you should reconsider the next time you think about doing the same thing to others!
Comment by
Noteable on May 09, 2024 1:26pm
Angler101 - your further self incrimination of falsely accusing me is proof enough of your guilt. You'll need a good lawyer.
Comment by
Lesalpes29 on May 09, 2024 11:40am
5M is not that much if you consider the cost. The conditions are not met yet to have a big partner with big $ to step in it seems. GL