Oncolytics Biotech Inc T.ONC

Immunotherapy: Oncolytic Viruses now on stage

[Noteable]

May 16, 2024   - " immunotherapies are emerging that could expand the benefits to more cancer patients, including those with cold tumours. These approaches include combination therapies using more effective immune checkpoint inhibitors with other agents, including chemotherapy and drugs in trials, to prime the immune system and enhance tumour recognition.

Ongoing research into immunotherapy could herald an era of targeted and tailored treatments. These include oncolytic viruses that can attack cancer directly ... "


https://theconversation.com/unlocking-the-bodys-defences-understanding-immunotherapy-226858

[Noteable]

Interesting work on how CD8+ T cells help kill cells infected with a virus, particularly knowing that pelareorep is able to stimulate the immune system and expand CD8+ TiLs cells in the tumor microenvironment (TME) and remodel the TME. In a cancer, pelareorep is the virus in the above mechanism and is able to remodel the TME, and in so doing in advance of the addition of an immune checkpoint