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Bullboard - Stock Discussion Forum Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and... see more

TSX:ONC - Post Discussion

Oncolytics Biotech Inc > ONCY Q2-2024 earnings call Pelareorep as a backbone therapy
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Post by Noteable on Aug 10, 2024 12:44pm

ONCY Q2-2024 earnings call Pelareorep as a backbone therapy

Tom Heineman: " ...We presented an abstract detailing pela's ability to induce the expansion of tumor-infiltrating lymphocytes or TILs across multiple cancers, including breast, pancreatic, and colorectal cancer. Pela's ability to expand TIL populations is important because TIL expansion correlates with tumor response. These data further highlight pela's immunotherapeutic mechanism of action and its promise as a backbone immunotherapy for multiple cancer indications.
 
Taken together, we are extremely excited about the advancements across our pipeline and the growing body of clinical data showcasing pela's broad therapeutic potential."

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" [In] the next study in breast cancer, we are not planning to compete with in Enhertu ,,,  We would be coming in and recruiting patients who can either not receive in Enhertu, for example, or who have failed in Enhertu.

And for those groups, the only options really available are traditional chemotherapy for the large -- majority of those patients. 


And so actually ....  I suspect that there will be a pretty high demand for patients' participation in a study that offers something with clear earlier data that improves upon standard of care chemo, if you see what I'm saying. In other words, I think there'll be plenty of patients who would be looking for a better options than what would otherwise be available. So I would anticipate that the enrollment into the study would be reasonably straightforward.
 "
Comment by Noteable on Aug 10, 2024 6:08pm
At the latest earnings call Tom Heineman commented on ONCY's mBC registration study design for pelareorep + nab-paclitaxel as similar to the model that Pfizer and Daiichi used for the CDK4/6 inhibitor and antibody drug conjugate (ADC), respectively, for their FDA approvals,  Heineman stated that ... " the model that we're following is very similar to the ...more  
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