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Bullboard - Stock Discussion Forum Resverlogix Corp T.RVX

Alternate Symbol(s):  RVXCF

Resverlogix Corp. is a Canada-based late-stage biotechnology company. The Company is engaged in epigenetics, with a focus on developing therapies for the benefit of patients with chronic diseases. Its epigenetic therapies are designed to regulate the expression of disease-causing genes. The Company's clinical program is focused on evaluating its lead candidate apabetalone (RVX-208) for the... see more

TSX:RVX - Post Discussion

Resverlogix Corp > re - Not good for the potential of apabetalone as a Covid-19
View:
Post by general360 on Nov 29, 2021 2:58pm

re - Not good for the potential of apabetalone as a Covid-19

not sure Bear looks at stockhouse any longer, but he just posted this on agoracommie

https://agoracom.com/ir/Resverlogix/forums/discussion/topics/770557-not-good-for-the-potential-of-apabetalone-as-a-covid-19-therapy/messages/2338952#message

wondering about the significance of this... a couple things caught my eye in the abstract he posted:

in the Summary section there is this line "Knockouts of BRD3 or BRD4 in cells overexpressing ACE2 exacerbate SARS-CoV-2 infection; "

and in the discussion portion this:  "Because most BET inhibitors do not distinguish between the different BET proteins and inhibit all of them indiscriminately, our study urges caution with the clinical use, prophylactic or therapeutic, of pan-BET inhibitors in people at risk or afflicted with COVID-19."

that doesn't jive w/ my understanding:


thought we were NOT a pan-BET inhibitor? 
thought we hit BRD4, not both BRD3 and BRD4?  or was it BRD2 and not both BRD3 and BRD4?

am i missing something?  maybe someone can ask Bear on agora? i would think this would be *good* for us?!

maybe that's why we languish....

thx.....

Comment by narmac on Nov 29, 2021 3:25pm
,,yea,,,boooyyy,,,hammer that share price,,,hammer it big time!!!!,,,,,,sell those shares into the market at what ever the bid is on the board,,,,these achievments from our team will certainly garner more DSUs and RSUs next quarter,,,wooohoooo!!! ,,,this company is nothing short of a joke,,,,
Comment by narmac on Nov 29, 2021 3:51pm
Hummmmm,,,,,Notice more often than not,,,,,when RVX gets hammered BTI goes up,,,,,I assume shareholders are taking $$$ off red and puting it on black for this round!!
Comment by general360 on Nov 29, 2021 5:05pm
what a nice close that was..... the DM effect?  a result of Bear's posting something not good for RVX chances vs COVID?  a financing coming? a full TEN PERCENT, way to go team! u get RSU's and u get RSU's....... the butterfly effect... a butterfly flaps its wings in indonesia and poof, causes a hurricane in mexico....if the rvx butterfly flaps his gums in say, north africa ...more  
Comment by narmac on Nov 30, 2021 10:00am
aaaccchhhhh,,,,its a sure thing DMcC is not the guy doing business,,,he is the talking head for this outfit. No non-professional is courting any bioitech or biotech service or other in cutting edge science protocol. I just dont believe it,,,,,I think our CEO is not even part of the meetings at times,,,,it looks that way cuz what he thinks he knows as being fact is actually gibberish from a ...more  
Comment by BearDownAZ on Nov 30, 2021 12:59pm
"thought we were NOT a pan-BET inhibitor? thought we hit BRD4, not both BRD3 and BRD4?  or was it BRD2 and not both BRD3 and BRD4?" My understanding of the published characterization of apabetalone is that it is not selective to BRD2, BRD3 or BRD4; however, it is more selective for binding to and inhibiting the second bromodomain (BD2) than BD1 irrespective of BRD2, BRD3 or ...more