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Bullboard - Stock Discussion Forum Sernova Corp T.SVA

Alternate Symbol(s):  SEOVF

Sernova Corp. is a Canada-based clinical-stage biotechnology company, which is developing therapeutic cell technologies for chronic diseases, including insulin-dependent diabetes, thyroid disease, and blood disorders that include hemophilia A. The Company is focused on developing a functional cure for insulin-dependent diabetes with its therapeutic cell technology, the Cell Pouch System, a... see more

TSX:SVA - Post Discussion

Sernova Corp > C-Peptide, why the body likes it :)
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Post by jwallisca on Nov 27, 2020 4:38pm

C-Peptide, why the body likes it :)

It turns out that if a person wasn't producing C-Peptide and somehow is now, that is a Big Deal.

The two links below give different types of information. The second, about the C-Peptide Test, is the much easier one to read for the lay person.

This link gives a long detailed, medical treatise on what C-Peptide is used for in the body including reducing inflammation, especially of the vascular (blood vessels) system. I have provided the Conclusions for a quick and dirty reference that having C-Peptide IS a good thing for the human body.

CONCLUSIONS AND FUTURE OUTLOOK

From the multifaceted effects of C-peptide discussed above, it should be clear that the peptide can no longer be considered an irrelevant by-product of insulin biosynthesis. Its specific binding to cell membranes, its particular intracellular signaling pattern with end effects involving activation and enhanced expression of eNOS and Na+,K+-ATPase, and its activation of several important transcription factors all attest to the peptide being a bioactive endogenous peptide in its own right. Extensive studies in animal models of diabetes and early clinical trials in type 1 diabetic patients demonstrate that replacement of C-peptide results in beneficial effects on the diabetes-induced functional and structural abnormalities of peripheral nerves, the kidneys, and the brain. Much remains to be learned about C-peptide physiology, but even a cautious evaluation of the available evidence presents in plain sight the picture of a previously unrecognized endogenous peptide with therapeutic potential. Since no disease-modifying therapy is available for patients with microvascular complications of type 1 diabetes, it can be hoped that the ongoing development of a long-acting C-peptide (75) will facilitate further clinical trials and allow definition of C-peptide’s potential role in the therapy of type 1 diabetes.

C-Peptide uses in body - Link

This link details the C-Peptide Test and what it reveals about the person being tested.
C-Peptide Test and uses of - Link
Comment by BioTeck on Nov 27, 2020 4:59pm
Oh really Wally. And at what levels is C-Peptide significant? Also, what other hormones along with C-Peptide are required to reverse diabetes? Just because you can detect something doesn' t mean its at theraputic levels.  Come on bud, you're an engineer, you aren't stupid. If the pouch had cured and reversed diabetes in those 5 patients, you'd be a millionaire if you owned ...more  
Comment by jammingthepipeline on Nov 27, 2020 5:19pm
Thanks for explaining your point of view in a very clear and intelligent way. That is indeed what a public board is all about. Wishfull thinking is never a good idea when you invest money.
Comment by jammingthepipeline on Nov 27, 2020 5:20pm
Thanks for explaining your point of view in a very clear and intelligent way. That is indeed what a public board is all about. Wishfull thinking is never a good idea when you invest money.
Comment by BioTeck on Nov 29, 2020 7:32pm
In Sweden, a 7-year-old girl receiving intramuscular autologous islets after a total pancreatectomy was reported; this subject had detectible C-peptide but failed to gain insulin independence. Google that Wally, just goes to show you can have C Peptide with ZERO effect on insulin since you don't seem to believe me.
Comment by down_inGT on Nov 29, 2020 8:11pm
Why are you so hell bent on wanting to prove this company and their product not viable? Do you really own shares? If I listen to only you, I should really be selling my shares, I try to be open minded and do my own DD and try to gauge other posters views, but you have got to be the worst,
Comment by palladium17 on Nov 29, 2020 8:42pm
DowninGt Please do not listen to these idiots.
Comment by BioTeck on Nov 30, 2020 12:33am
Balancing out the pumpsters. I feel what is posted here has 0 effect on share price, future or present. Pump or bash. I'm posting my opinions, if you don't like my opinion post your own. There is no point of a discussion board where all the posters pump the company . The only pumping sva needs is a pumping of the share price. If you are so bullish on it, buy a few million shares. Don't ...more  
Comment by Redbaron2211 on Nov 29, 2020 9:05pm
Bio it doesn't say zero insulin it says "failed to gain insulin independence". Cpeptide is a byproduct of the formation of insulin so she also had detectible natural insulin but not enough for insulin independence. This only reinforces the importance of the cell pouch. Imagine instead of receiving those islets intramuscular she had a cell pouch implanted where they can actually ...more  
Comment by Sonny7 on Nov 30, 2020 2:49am
I think I challenged you on this before red, more or less in the form of a riddle asking you to find a flaw in your post under the heading or labeled as “blowing smoke” in relation to vascularized islets.  It’s about “vascularized islets” and I’m not sure the term is correct. My understanding is that the cell pouch is put in place and is void. After placement of the pouch the body tissue ...more  
Comment by jwallisca on Nov 30, 2020 9:34am
S7: Your question is effectively answered in the vernacular by what you wrote. Today's news is effectively on this subject and will be released in a detailed Scientific manner by Dr. Witkowski in Jan 2021. I have no idea why Stockhouse's "post a link" didn't work in a previous post... Attempt #2 with a different method. Mon Nov 30th, 2020 TheNewsWire9:11 AMSernova ...more  
Comment by woundedknee on Nov 30, 2020 9:39am
What's this..about the umpteenth conference presentations in the last several months? Maybe we can hope some attending will see the potential. Of course this is still six weeks away...gl still long
Comment by Sonny7 on Nov 30, 2020 9:48am
Powerful news methinks, woundedknee. Witkowski in front of 600 transplant surgeons and he won’t be there to speak of failures. I’m optimistic that he will tell of trial results to gain a whole lot of attention in the World. 
Comment by woundedknee on Nov 30, 2020 9:52am
Sonny..at least it's worded "investigator" presentation rather than the stale "investor" presentation. Maybe jwall can analyse that for us.  just joshing walli..
Comment by Sonny7 on Nov 30, 2020 9:41am
Wally, I wasn’t asking a question per se. I was suggesting that red had some terminology cross threaded. 
Comment by Redbaron2211 on Nov 30, 2020 9:43am
Sonny your not wrong in the fact that the pouch is pre-vascularized. But it is done so the islets can become vascularized within the cell pouch and deliver oxygen and nutrients to the different cells (beta ext//) while allowing them to secrete insulin back into the blood stream. These islets are basically mini organs that need to be highly vascularized more so then the rest of the pancreas. Take a ...more  
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