StageZero Life Sciences Ltd T.SZLS

Grail even less accurate than previously thought

[LithLover]

Grail test found to have even more false positives than before. Imagine taking the test being told you have cancer and than finding out the test was only 38% accurate.  

29.8% of the participants with false alarms underwent invasive procedures

Sept 12, 2022

https://www.medtechdive.com/news/amid-merger-turmoil-illuminas-grail-unit-reports-downturn-in-accuracy-of/631583/

• Updated data on Grail’s multi-cancer early detection blood test Galleri suggest the diagnostic is less accurate than previously thought. 
• Last year, Grail reported that 44.6% of patients with positive test results actually had cancer. In the latest analysis, the figure, known as the positive predictive value, has fallen to 38.0%.
• News of the falling predictive power seen in the study, which used an old version of Galleri, comes amid growing doubts about the fate of the Illumina-Grail merger, which the European Commission has blocked.

[Nailbiter2]

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[Liked2Think]

Has there ever been any 3rd party verification that the Aristotle test is any better or is that just another thing investors should just believe from a ceo that hasn't been able to keep his word multiple times in the past?

[LithLover]

I'm just pointing out that Grail is under 50% accurate and almost 1/3 of the false positive people went in for invasive procedures after being told they may have cancer. Why you being so defensive?  You OK?  

[Liked2Think]

How am I being defensive when I call out a one sided opinion of the bigger company in this space? Your saying GRAIL does not have the best test while compared against Aristotle. Ok fine you are welcome to believe that but how can you compare the two? So far it looks like Aristotle hasnt sold at all except for a few tests "maybe".   Again CARE made $1M a quarter when Stage

[Nailbiter2]

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[LithLover]

Glad you asked Here are the published results: Grail in Annals of Oncology: https://www.annalsofoncology.org/article/S0923-7534(21)02046-9/fulltext Overall sensitivity for cancer signal detection was 51.5% (49.6% to 53.3%); sensitivity increased with stage [stage I: 16.8% (14.5% to 19.5%), stage II: 40.4% (36.8% to 44.1%), stage III: 77.0% (73.4% to 80.3%), stage IV: 90.1% (87.5% to 92.2

[Liked2Think]

How many of Stage's patients that have been diagnoised with cancer through aristotle actually had cancer?  Is there any real world data at all? Aristotle classified cancer profiles with sensitivities from 55.6-100% What were the numbers betwen the two vastly different percentages?  Is a 55.6% great?  Yes better than 38% and maybe the numbers overall were closer to

[Nailbiter2]

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