Theratechnologies Inc T.TH

Docetaxel resistance mechanisms

[jeffm34]

https://www.sciencedirect.com/science/article/pii/S0753332221006065

The article talks about EMT- mediated metastasis. I think there is a link with the Sortilin receptor and Progranulin. 

"In addition, we have observed an increase in protein expression of the transcription factors SNAIL (SNAI2) and SLUG (SNAI1) in progranulin-treated breast cancer cell lines (Additional file 2) suggesting that progranulin also increase epithelial-mesenchymal transition (EMT) features of breast cancer cells."
 

Also from the original article are suggested ways to overcome docetaxel resistance. 

" The final strategy is brining bioengineering to the help of biology. To date, different kinds of nanocarriers have been developed for delivery of DTX in cancer therapy and enhancing its intracellular accumulation"

[Wino115]

Nice find -- that's a great endorsement on two fronts.  One, it once again documents how powerful taxanes are in stopping cancer cell --so we know this is a toxin the industry see's as highly effective if it can get in the tumor.  Second, TH1902 is one of the three bioengineering methods needed to increase the effectiveness of the drug around resistance --using nanotechnology

[jeffm34]

The other effect may be on Progranulin which binds to Sortilin.  " Progranulin induces metastasis in breast cancer models"