Theratechnologies Inc T.TH

Encouraging

[scarlet1967]

They are now officially looking for someone to explore siRNA/mRNA opportunities.

Check out this job at Theratechnologies Inc.: Scientist; siRNA Specialist
https://www.linkedin.com/jobs/view/2893910019

[scarlet1967]

Check out this job at Theratechnologies Inc.: Analytical Scientist https://www.linkedin.com/jobs/view/2893916261

[scarlet1967]

More about the technology! Given the ability to knock down, in essence, any gene of interest, RNAi via siRNAs has generated a great deal of interest in both basic and applied biology. Delivery of siRNA via nanoparticles has shown promise. There are several advantages that this therapy has over small molecules and antibodies. It can be administered quarterly or every six

[scarlet1967]

These new job postings to me is quite interesting although early in the process it seems the oncology program/programs are progressing well thus far and the company has ambitious plans/goals for them. Check out this job at Theratechnologies Inc.: Chemical Scientist https://www.linkedin.com/jobs/view/2893922216

[qwerty22]

Seems exciting. I would generally think of this as the expansion of the SORT1 technology that would come after validation of TH1902 in the present trial. After all if they have nothing coming out of this trial it's much harder to get the investment in follow on molecules. Having said that, in the scheme of things, it's a pretty small investment in one scientist and bench fees. So again it

[qwerty22]

Here is an example of an siRNA conjugate developed by academic researchers at Duke that delivers siRNA to prostate cancer by targeting the PSMA antigen. https://www.qpcrupdate.info/mcnamara-sirna-2006.pdf

[Wino115]

Would they bother hiring scientist at the cutting edge around ways to possibly kill tumor cells if they weren't extremely confident of the POC signs they've seen so far.  I just don't think they would.  To me, it's one more positive around the concept showing that it works.  As for efficacy, we'll have to see, but it seems to have moved from conceptual invivo to

[jfm1330]

This is as close as having the proof they have proof of concept for TH19P01. Why would you start the search to hire a RNA specialist if you are not sure your peptide conjugate works at entering cells by binding to sortilin? It is not 100% sure they have the proof of concept, but it is close. Add that to the feedback from the management's meetings with big investors. It also shows a willingness

[palinc2000]

Now I see the difference between a good sign and proof of concept Thank you so much JMF you are the greatest!!! You are the best fact based scientist on this mb

[SPCEO1]

As I noted at the start of this debate today, I think the company has already basically told us they have proof of concept/partial tumor regression/stable disease. And I noted that the scientists among us would not likely agree to that, understandably so, from a technical perspective until they got the test results they need to see it. For investors, however, I think we can be encouraged by how

[palinc2000]

Can you elaborate how that would be different from the current PDC ?

[Wino115]

You know I'm not a science guy up here, but my limited understanding is that if you think about how to stop tumor growth, oncology drugs have been about killing tumor cells so they no longer proliferate and it shrinks.  First you had toxins with no targeting, then targeting came along and you attached toxins, then radionucleoid, and now bits of RNA that disrupt the intracellular mechanism

[qwerty22]

Maybe the best way to think about it is delivering a different type of bomb using the same targeting system. Maybe call it a stealth bomb. What siRNA does is essentially turn off or silence genes. You could basically pick any gene that was essential to cancer growth and silence that. It has the feel of an intervention that can be highly focused. Part of the problem with siRNA is the difficulty in

[JayjayUSA12007]

Quote:"Maybe the best way to think about it is delivering a different type of bomb using the same targeting system. Maybe call it a stealth bomb. What siRNA does is essentially turn off or silence genes. You could basically pick any gene that was essential to cancer growth and silence that. It has the feel of an intervention that can be highly focused. Part of the problem with siRNA is the

[scarlet1967]

This is another recent paper explaining how the genetic disruption in cancer cells using the technology will have advantages versus conventional cancer treatments, the issue has been the delivery so an siRNA conjugate will open up promising therapeutic opportunities. Again they really seem to go for it!! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309123/#!po=0.649351