Bullboard - Stock Discussion Forum Theratechnologies Inc T.TH

Alternate Symbol(s): THTX

Healthcare Biotechnology

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs... see more

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Theratechnologies Inc > PDC's

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Post by TH1902 on Jul 20, 2022 3:53pm

PDC's

Currently there are only 2 PDC's that have FDA approval (article is one year old).

Some info on current PDC's here:

https://www.biochempeg.com/article/199.html

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Comment by jfm1330 on Jul 20, 2022 4:34pm

In my view, Melflufen in not an PDC. It's a prodrug. It's not aiming at a cellular target, the added amino acid is there just to increase the lipophilicity and allow the prodrug to enter the cells. Once inside the cells, the prodrug is cleaved in two parts releasing the free drug. It has nothing of the targeted element and selective distribution associated with the principle behingd PDCs ...more

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Comment by jfm1330 on Jul 20, 2022 4:39pm

By the way, it seems Melflufen has beed withdrawn from the market because of excess deaths in phase III confirmatory trial. So it is now irrelevant to argue if it's an approved PDC or not, it is no longer approved. Always remember that in cancer you can have fast approval, but confirmatory trials are requested for long term safety and to gather data on a higher number of patients. https://www ...more

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