Theratechnologies Inc T.TH

Fatty heart

[scarlet1967]

 

This study started while ago and the status was unknown, it was recently updated as complete so I guess there were some Covid related issues for the long delay. The purpose was to evaluate the relationship between GH deficiency and fat accumulation inside the heart muscles. Obviously obesity/high levels of VAT will be causing cardiac steatosis but HIV and long term use of antivirals also disturbs glucose/fat metabolism resulting in high blood sugar/fat. That’s the thinking among others behind increased prevalence of fatty liver/heart among PLWH. So it will be interesting to know what was the conclusion. Again point is there are several ongoing studies evaluating various therapeutic benefits of Tesamorelin and some are for serious conditions such as heart attack although

ischaemic heart diseases are more common metabolic heart diseases are still very common specifically among PLWH.

 

Growth Hormone Dynamics and Cardiac Steatosis in HIV - Full Text View - ClinicalTrials.gov

[stephanedodier]

Thanks for sharing Scarlet,    I was wondering where was our friend Dr. Steven K. Grinspoon ...   Seriously, it's been a long time.... is M. Grinspoon still part of the THTX family ?

[scarlet1967]

You are welcome, he is one of the three current advisors on the website also both he and his hospital are entitled to milestone payments when and if the NASH trial progresses so he is highly motivated to have that trial started not only financially but also because of all the hard academic work. https://www.globenewswire.com/news-release/2020/02/04/1979391/0/en/Theratechnologies-Signs-Agreements

[Lee430]

I do feel empathy for Dr Greenspoon as it appears a promising piece of his life’s work & hopes are withering away on the vine…Hopefully SOON Thera will show us their plan to get this indication over the finish line or sell this asset off to help support the Sort1+ platform research.